. "http://www.isvav.cz/projectDetail.do?rowId=NC7503"^^ . "Assessment of the relation of the angiogenesis density to the parametrs of kinetics of myeloma cells ( propidium iodide index/CD138 and markers of apoptosis -annexin V-FITC, PARP, caspase 3 and 8, p53 and Bcl-2) and cyclin D1. Comparison of the stage of angiogenesis in the bone marrow of patients with MGUS, smoldering and active form of myeloma, patients in stable-plateau vs. active-relapsing phase of disease and disease in stages I-III (Durie-Salmon). Assessment of the relation of stage of angiogenesis to selected angiogenic serum factors (VEGF, HGF, bFGF, sSyndecan-1 and Fas). Comparison of stage of angiogenesis in patients with favourable and missing response to conventional and high dose chemotherapy with transplantation of autologous hemopoietic cells respecting relatio to parameters of apoptosis and overall survival"@en . "Zhodnocen v\u00FDznam vy\u0161et\u0159en\u00ED angiogenezy kostn\u00ED d\u0159en\u011B, s\u00E9rov\u00FDch hladin s VCAM-1, sHGF, sOPG, sSyndecanu-1, sFas, expresi Bcl-2, PARP, p53, casp\u00E1zy 3 a 8 i proliferace a apopt\u00F3zy myelomov\u00FDch plazmocyt\u016F u mnoho\u010Detn\u00E9ho myelomu a MGNV."@cs . "NC7503" . "multiple myeloma;angiogenesis;angiogenic cytokines;index of proliferation;annexin-V index;markers of apoptosis;prognostic factors;myeloma prognosis"@en . "Angiogenesis, angiogenic cytokines and indices of plasma cell kinetics in multiple myeloma: clinical and prognostic significance"@en . . . "2006-06-23+02:00"^^ . . . "Zhodnocen\u00ED vztahu stupn\u011B angiogeneze k parametr\u016Fm kinetiky myelomov\u00FDvh bun\u011Bk (propidium-jodidov\u00FD index/CD138 a ukazatele apopt=ozy tj. annexin-VFITC, PARP, casp\u00E1sa 3 a 8, p53 a Bcl-2) a cyklinu. Srovn\u00E1n\u00ED stupn\u011B angiogeneze v kostn\u00ED d\u0159eni u jedinc\u016F s MGUS, doutnaj\u00EDc\u00ED a aktivn\u00ED formou mnoho\u010Detn\u00E9ho myelomu, nemocn\u00FDch ve stabiln\u00ED - plateu vs. aktivn\u00ED-relabuj\u00EDc\u00ED f\u00E1zi nemoci a ve stadi\u00EDch I-III ( dle Durieho-Salmona). Zhodnocen\u00ED vztahu stupn\u011B angiogeneze k vybran\u00FDm angiogenn\u00EDm p\u016Fsobk\u016Fm (VEGF, HGF, bFGF, sSyndecan-1 a Fas) v s\u00E9ru. Srovn\u00E1n\u00ED stupn\u011B angiogeneze u nemocn\u00FDch s p\u0159\u00EDznivou vs. chyb\u011Bj\u00EDc\u00ED odezvou ke konven\u010Dn\u00ED i vysokod\u00E1vkovan\u00E9 chemoterapii s transplantac\u00ED autologn\u00EDch krvetvorn\u00FDch bun\u011Bk a to i ve vztahu ke st\u011B\u017Eejn\u00EDm ukazatel\u016Fm prog\u00F3zy a celkov\u00E9mu p\u0159e\u017Eit\u00ED." . . . "12"^^ . . "angiogenesis" . "12"^^ . . . "prognostic factors" . . . "The significance of examination of bone marrow angiogenesis, serum levels of sHGF, sOPG, sSyndecan-1, sFas, expression of Bcl-2, PARP, p53 and of proliferation and apoptosis of plasmocytes in myeloma and MGUS has been evaluated."@en . . "Angiogeneze, angiogenn\u00ED cytokiny a parametry kinetiky plazmocyt\u016F u mnoho\u010Detn\u00E9ho myelomu : klinick\u00FD a prognostick\u00FD v\u00FDznam" . . . "markers of apoptosis" . "annexin-V index" . "0"^^ . . . . "multiple myeloma" . "1"^^ . . "index of proliferation" . "angiogenic cytokines" . "1"^^ .