. . "0"^^ . "V\u00FDzkum interakce metabolismu fluorovan\u00FDch pyrimidin\u016F a ionizuj\u00EDc\u00EDho z\u00E1\u0159en\u00ED, vliv na predikci efekt\u016F chemoradioterapie" . "2"^^ . "capectiabine" . "predicitive factors;chemoradiotherapy;5-fluorouracil;capectiabine;gemcitabine;TS;TP;DPD"@en . "2"^^ . "1"^^ . "5-fluorouracil" . "1"^^ . "The aims did not trued in all planned extent. It is not enclosed acknowledgement of receipt original article with results in journal with Impact factor."@en . . . "NC7372" . "2005-07-18+02:00"^^ . "The project is aimed to create and verifity a set of predictors for chemoradiotherapy with fluorinated pyrimidines 5-FU, capecitabine and gemcitabine. It is based on known predictors - pyrimidines metabolising enzymes. The project examines changes in pyrimidines metabolising enzymes caused by a ionizing radiation in tumor and non-tumor tissues, presumably within the reparative post- radiation reaction. The levels of enzymes are to be established in tissue cultures and in bioptic material of rectal cancer before and after radiation employing the methods RT PCR and HPLC. A correlation of the values will be established."@en . . . "gemcitabine" . . "Anotovan\u00E9 c\u00EDle nebyly spln\u011Bny v cel\u00E9m pl\u00E1novan\u00E9m rozsahu. Nen\u00ED p\u0159ilo\u017Eeno potvrzen\u00ED o p\u0159ijet\u00ED p\u016Fvodn\u00ED pr\u00E1ce s v\u00FDsledky do \u010Dasopisu s IF."@cs . . . . "predicitive factors" . . "TS" . . "The research of interactions between metabolism of fluorinated pyrimidines and ionizing radiation, influence on prediction of chemoradiotherapy effects"@en . . . . . "Projekt je zam\u011B\u0159en na vytvo\u0159en\u00ED a ov\u011B\u0159en\u00ED panelu prediktor\u016F chemoradioterapie s fluorovan\u00FDmi pyrymidiny 5-fluorouracilem, capecitabinem a gemcitabinem. Vych\u00E1z\u00ED z dosud zn\u00E1m\u00FDch prediktor\u016F, pyrymidiny metabolozuj\u00EDc\u00EDch enzym\u016F. Projekt ov\u011B\u0159uje zm\u011Bny v aktivit\u011B pyrymidiny metabolizuj\u00EDc\u00EDch enzym\u016F nast\u00E1vaj\u00EDc\u00EDch pod vlivem ionizuj\u00EDc\u00EDho z\u00E1\u0159en\u00ED v n\u00E1dorov\u00E9 i nen\u00E1dorov\u00E9 tk\u00E1ni, z\u0159ejm\u011B jako sou\u010D\u00E1st poradia\u010Dn\u00ED repara\u010Dn\u00ED reakce. Stanovuj\u00ED se hladiny enzym\u016F ve tk\u00E1\u0148ov\u00FDch kultur\u00E1ch a v bioptick\u00E9m materi\u00E1lu ca rekta p\u0159ed a po oz\u00E1\u0159en\u00ED metodikami RT PCR (transkripty) a HPLC (proteiny). Bude zji\u0161t\u011Bna korelace n\u00E1lez\u016F. V\u00FDsledky umo\u017En\u00ED predikovat \u00FA\u010Dinnost i toxicitu chemoradioterapie a kontraindikovat chemoradioterapii u nemocn\u00FDch s genetick\u00FDm defektem metabolismu a ohro\u017Een\u00FDch t\u011B\u017Ekou toxicitou." . . . . "http://www.isvav.cz/projectDetail.do?rowId=NC7372"^^ . "TP" . "chemoradiotherapy" .