"2"^^ . . . "2004-07-12+02:00"^^ . "Nov\u00E9 poznatky o vztahu HPV k etiologii a progn\u00F3ze nemocn\u00FDch s karcinomy orofaryngu a dutiny \u00FAstn\u00ED."@cs . "2"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NC6441"^^ . "1"^^ . . . "1"^^ . . . . . "HPV" . "Significance of human papillomavirus in aetiology and prognosis of oropharyngeal and oral cancer"@en . "0"^^ . . "tumors" . "To detect prevalence and type of HPV in the tissue removed from oropharyngeal/oral carcinoma by PCR,DNA hybridization and sequencing.To detect in the same group of patients and in the group of controls presence and type of HPV in cytology material. To determine whether presence and type of HPV is an independent risk factor of oropharyngeal/oral cancer.To determine whether some other factors (kife style and habits) are also an independent risk factors of oropharyngeal/oral cancer. To determine the presence of HPV antibodies in cancer patients and in healthy controls. To follow-up the antibody level in relation to clinical outcome.To find out whether HPV antibodies might serve as a marker for oropharyngeal/oral cancer risk or for its recurrence."@en . "NC6441" . "oropharynx" . . . "DNA hybridization" . . "V\u00FDznam lidsk\u00FDch papillomavir\u016F v etiologii a prognoze karcinomu orofaryngu a dutiny \u00FAstn\u00ED" . . "oropharynx;oral cavity;tumors;HPV;PCR;DNA hybridization;risk factors"@en . "PCR" . . . "Zjistit v\u00FDskyt a typ HPV v tk\u00E1ni odebran\u00E9 z n\u00E1dor\u016F orofaryngu a dutiny \u00FAstn\u00ED pomoc\u00ED PCR a DNA hybridizace a sekvenace. U stejn\u00FDch pacient\u016F a u zdrav\u00FDch kontrol zjistit v\u00FDskyt a typ HPV v cytologick\u00E9m materi\u00E1lu z\u00EDskan\u00E9m z v\u00FDplachu dutiny \u00FAstn\u00ED. Zjistit, zda p\u0159\u00EDtomnost a typ HPV je nez\u00E1visl\u00FDm rizikov\u00FDm faktorem vzniku orofarynge\u00E1ln\u00EDho a or\u00E1ln\u00EDho karcinomu. Zjistit, zda n\u011Bkter\u00E9 dal\u0161\u00ED faktory (\u017Eivotn\u00ED styl a n\u00E1vyky) jsou tak\u00E9 nez\u00E1visl\u00FDmi rizikov\u00FDmi faktory pro vznik t\u011Bchto n\u00E1dor\u016F. U pacient\u016F s n\u00E1dory a u zdrav\u00FDch kontrol zjistit prevalenci protil\u00E1tek proti HPV. Sledovat hladinu protil\u00E1tek v z\u00E1vislosti na klinick\u00E9m v\u00FDvoji. Zjistit, zda p\u0159\u00EDtomnost anti-HPV protil\u00E1tek m\u016F\u017Ee slou\u017Eit jako marker rizika vzniku karcinomu nebo jeho recidivy." . . "oral cavity" .