. "Non-Hodgkin\u015B Lymphomas;chromosomal changes;Translocation;Amplification;CGH;FISH;Oncogenes;Tumor suppressor genes"@en . . "3"^^ . . "P\u0159esn\u00E9 ur\u010Den\u00ED genetick\u00FDch zm\u011Bn vedouc\u00ED k aktivaci onkogen\u016F a inaktivaci tumor supresorov\u00FDch gen\u016F metodou CGH a FISH u nemocn\u00FDch s folikul\u00E1rn\u00EDm lymfomem (FL),lamfomem pl\u00E1\u0161\u0165ov\u00E9 z\u00F3ny(MCL) a dif\u00FAzn\u00EDm velkobun\u011B\u010Dn\u00FDm lymfomem (B-DLCL). Mapov\u00E1n\u00ED chromosomov\u00FDch oblast\u00ED nej\u010Dast\u011Bji zahrnut\u00FDch do chromosomov\u00FDch zm\u011Bn metodou FISH s genov\u011B specifick\u00FDmi sondami. Sledov\u00E1n\u00ED ztr\u00E1ty heterozygozity (LOH) gen\u016F p53,p16 a Rb metodou FISH.Ur\u010Den\u00ED diagnostick\u00E9ho a prognostick\u00E9ho v\u00FDznamu nalezen\u00FDch zm\u011Bn. U\u017Eit\u00ED specifick\u00FDch chromosomov\u00FDch zm\u011Bn k detekci minim\u00E1ln\u00ED residu\u00E1ln\u00ED nemoci." . "0"^^ . . . "3"^^ . "1"^^ . "Translocation" . . "Amplification" . "V\u0161echny c\u00EDle pr\u00E1ce byly spln\u011Bny, jedna publikace v impaktovan\u00E9m \u010Dasopise ji\u017E vy\u0161la, dal\u0161\u00ED se chyst\u00E1. K ekonomick\u00E9 \u010D\u00E1sti nejsou p\u0159ipom\u00EDnky. Publikace: Leukemia (IF 4.293)."@cs . "http://www.isvav.cz/projectDetail.do?rowId=NC6209"^^ . "chromosomal changes" . "CGH" . "Characterization of types of genetic lession leading to activation of oncogenes and inactivation of tumor suppresor genes in three main types of NHL. Using fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH) for detection of chromosomal changes in mantle cell lymphoma (MCL),folicular lymphoma (FL) and diffuse large B-cell lymphoma (B-DLCL). Mapping of most frequent regions involved in changes by FISH with gene specific probes Following of lost of heterozygozity (LOH) for p53,p16 and Rb genes. Determination of diagnostic and prognostic importance of detected changes.Evaluation of minimal residual disease (MRD)."@en . "NC6209" . "0"^^ . . . "Oncogenes" . "The study of mech.of proto-oncog.activ.and tumor supressor genes inactiv.by fluresc.in situ hybridiz.(FISH)and compar. genomic hybridiz.(CGH)in pat.with non-Hodgkin\u015B lymph.(NHL)."@en . . "2003-07-31+02:00"^^ . "Studium mechanismu aktivizace onkogen\u016F a inaktivace tumor supresor. gen\u016F u nehodgkin. lymfom\u016F(NHL)met. komparativn\u00ED genomick\u00E9 hybrid.(CGH)a fluorescen\u010Dn\u00ED in situ hybrid.(FISH)." . . . . "Non-Hodgkin\u015B Lymphomas" . . . . . "FISH" .