. "NC6171" . . "0"^^ . . . "Byla vyvinuta metoda stanoven\u00ED isoprenu v dechu jako ukazatele endogenn\u00ED synt\u00E9zy cholesterolu. Byla vyvinuta origin\u00E1ln\u00ED metoda, umo\u017E\u0148uj\u00EDc\u00ED kvantifikaci fermentace vl\u00E1kniny ve st\u0159ev\u011B in vivo vylu\u010Dov\u00E1n\u00EDm metanu dechem. Metoda je pod\u00E1na k patentov\u00E9mu \u0159\u00EDzen\u00ED"@cs . . . . "C\u00EDlem \u0159e\u0161en\u00ED je z\u00EDskat data, jak lipidy pou\u017E\u00EDvan\u00E9 v um\u011Bl\u00E9 v\u00FD\u017Eiv\u011B ( zejm\u00E9na PUFA e-3 ) ovliv\u0148uj\u00ED chov\u00E1n\u00ED kolorekt\u00E1ln\u00EDho karcinomu v tk\u00E1\u0148ov\u00E9 kultu\u0159e ( metabolick\u00E9 zm\u011Bny, proliferace, apoptosa ). Je mo\u017En\u00E9 pozorovat obdobn\u00E9 metabolick\u00E9 zm\u011Bny v klinick\u00FDch podm\u00EDnk\u00E1ch po I.V. pod\u00E1n\u00ED tukov\u00E9 emulze u pacient\u016F s kolorekt\u00E1ln\u00EDm karcinomem ? Nejvhodn\u011Bj\u0161\u00ED laboratorn\u00ED vy\u0161et\u0159en\u00ED odvozen\u00E1 z experimentu in vitro budou zapracov\u00E1na do klinick\u00E9ho protokolu. Vybran\u00E1 vy\u0161et\u0159en\u00ED budou pou\u017Eita u pacient\u016F bez terapie po zji\u0161t\u011Bn\u00ED diagn\u00F3zy a po kr\u00E1tk\u00E9m pod\u00E1n\u00ED tukov\u00E9 emulze v pr\u016Fb\u011Bhu obvykl\u00E9 nutri\u010Dn\u00ED podpory." . "1"^^ . . "1"^^ . "Zm\u011Bna metabolismu lipid\u016F a jejich medi\u00E1torov\u00FDch \u00FA\u010Dink\u016F u pacient\u016F s kolorekt\u00E1ln\u00EDm karcinomem - perspektivn\u00ED vyu\u017Eit\u00ED v nutri\u010Dn\u00ED podpo\u0159e." . "colorectal carcinoma;lipid emulsions;artificial nutrition;tumor proliferation;tumor invasivity;polyunsaturated fatty acids;cholesterol"@en . "colorectal carcinoma" . "Changes of lipid metabolism and its mediator-related effects in patients with colorectal carcinoma - perspective impact in nutritional support."@en . . "polyunsaturated fatty acids" . . "2003-07-31+02:00"^^ . . . "http://www.isvav.cz/projectDetail.do?rowId=NC6171"^^ . . "artificial nutrition" . "The aim is to obtain data on the effects of lipids used in artificial nutrition (mainly PUFA n-3) upon characteristic of colored carcinoma in cell culture (metabiloc changes, proliferation, apoptosis). Is it possible ti find similar changes in clinical conditions after i.v. administration of lipid emulsions in patients with colorectal carcinoma? The most appropriate laboratory methods, based on experimental data in vitro, will be applied in clinical protocol."@en . "17"^^ . "lipid emulsions" . "tumor proliferation" . "17"^^ . "tumor invasivity" . . . .