"prognosis" . "iron metabolism" . . . "pathogenesis" . "Patogenetick\u00E1 \u010D\u00E1st:1.isolace mitochondri\u00E1ln\u00ED frakce z erytroidn\u00EDch bun\u011Bk kostn\u00ED d\u0159en\u011B,2.detekce mutac\u00ED mtDNA prost\u0159ednictv\u00EDm RFLP anal\u00FDzy,3.spektrofotometrick\u00E9 stanoven\u00ED aktivity a elektroforetick\u00E1 anal\u00FDza enzym\u016F d\u00FDchac\u00EDho \u0159et\u011Bzce. Klinick\u00E1 \u010D\u00E1st:1.korelace n\u00E1lez\u016F mutac\u00ED mtDNA s klinick\u00FDm obrazem a s ostatn\u00EDmi laboratorn\u00EDmi n\u00E1lezy 2.prognostick\u00FD v\u00FDznam v\u011Bne\u010Dkovit\u00FDch sideroblast\u016F u ostatn\u00EDch podtyp\u016F MDS ev.akutn\u00ED leukemie.3.Vztah RARS a n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED." . "0"^^ . . . "1"^^ . "respiratory chain" . "Zaveden\u00ED nov\u00E9ho diagnostick\u00E9ho testu p\u0159i l\u00E9\u010Debn\u00E9 metod\u011B MDS. Publikace: Sborn\u00EDk l\u00E9ka\u0159sk\u00FD"@cs . . "myelodysplaasia" . "1"^^ . . . "1"^^ . . . "1"^^ . "V\u00FDznam mutac\u00ED mitochondri\u00E1ln\u00ED DNA v patogenese z\u00EDskan\u00E9 sideroblastick\u00E9 anemie a ostatn\u00EDch podtyp\u016F myelodyplastick\u00E9ho syndromu" . "ring sideroblasts;myelodysplaasia;mitochondrial DNA;respiratory chain;pathogenesis;prognosis;iron metabolism;tumours"@en . . . "ring sideroblasts" . "http://www.isvav.cz/projectDetail.do?rowId=NC6001"^^ . "2003-07-31+02:00"^^ . "mitochondrial DNA" . . . . "The significance of mitochondri\u00E1l DNA mutations in the pathogenesis of refractory anaemia with ring sideroblasts"@en . . "NC6001" . . "Pathogenetical part:1.isolation of mitochondrial fraction from erythroid cwlls in bone marrow,2.detection of mtDNA mutations vy RFLP,3.determinantion of activity and quantity of enzymes of respiratory chain. Clinical part:1.correlation between mtDNA muitations and clinical features and other laboratory findings 2.significance of ring sideroblasts in other types MDS resp.acute leukemia 3.relationship RARS and tumours."@en .