"The retroviral vector-mediated transfer of drug resistance genes into hematopoietic cells will be optimized. Expression of the drug resistance genes will protect hematopoietic cells against toxic and mutagenic side effects of antitumor cytotoxic chemotherapy."@en . . . "0"^^ . "NC5727" . "retrovirus" . . "Drug resistance gene transfer into hematopoietic cells for protection against toxic and mutagenic effects of chemoterapy."@en . . "0"^^ . "2"^^ . . "P\u0159enos gen\u016F k ochran\u011B krvetvorn\u00FDch bun\u011Bk p\u0159ed toxick\u00FDmi a mutagenn\u00EDmi \u00FA\u010Dinky cytostatik" . "2"^^ . "1"^^ . "genov\u00E1 terapie" . . "kmenov\u00E9 bu\u0148ky" . "krvetvorba" . . . . "akyltranfer\u00E1za" . "transdukce" . "akylguanin" . "http://www.isvav.cz/projectDetail.do?rowId=NC5727"^^ . . "V\u00FDsledky prok\u00E1zaly, \u017Ee nelze vyu\u017E\u00EDt retrovirov\u00FD vektor SF1 MIH ( se 2 geny pro chemorezistenci) pro transdukci prim\u00E1rn\u00EDch lidsk\u00FDch krvetvorn\u00FDch bun\u011Bk z d\u016Fvodu n\u00EDzk\u00E9 v\u00FDt\u011B\u017Enosti.Z\u00EDskan\u00E9 v\u00FDsledky jsou d\u016Fle\u017Eit\u00E9 pro dal\u0161\u00ED projekty."@cs . . "progenitory" . . "akylguanin;akyltranfer\u00E1za;genov\u00E1 terapie;kmenov\u00E9 bu\u0148ky;krvetvorba;mdrl;progenitory;retrovirus;transdukce;vektor"@en . "Bude optimalizov\u00E1na metodika p\u0159enosu gen\u016F pro rezistenci na cytostatika do krvetvorn\u00FDch bun\u011Bk retrovirov\u00FDch vektor\u016F. Exprese vektor\u016F poskytne krvetvorn\u00FDm bu\u0148k\u00E1m ochranu p\u0159ed toxick\u00FDmi a mutagenn\u00EDmi \u00FA\u010Dinky cytostatik." . . "mdrl" . "2004-03-23+01:00"^^ . . .