"del(5q)" . "myelodysplasie" . "chromozom 5q" . "http://www.isvav.cz/projectDetail.do?rowId=NC5535"^^ . "antisense regulace" . "AML" . . . "1"^^ . . "NC5535" . "Z\u00EDskan\u00ED cenn\u00FDch v\u00FDsledk\u016F o expresi genu Smard5 a o existenci jeho alternativn\u00EDch transkrip\u010Dn\u00EDch forem. \u010C\u00E1ste\u010Dn\u011B charakterizov\u00E1n antisense transkript, kter\u00FD je nazv\u00E1n DAMS. Objev funkce Smad5alfa coby transduktor sign\u00E1lu BMP-4."@cs . . "3"^^ . "0"^^ . . "3"^^ . "2004-03-23+01:00"^^ . "MDS" . "0"^^ . . "leuk\u00E9mie" . "Genetick\u00E1 anal\u00FDza kandid\u00E1tn\u00EDch gen\u016F u akutn\u00ED myeloidn\u00ED leuk\u00E9mie a myelodysplastick\u00E9ho syndromu" . . "AML;antisense regulace;del(5q);genov\u00E9 exprese;chromozom 5q;leuk\u00E9mie;MDS;myelodysplasie;Smad5;supresorov\u00E9 geny"@en . "genov\u00E9 exprese" . . . "Smad5" . "Genetic Analysis of Candidate Genes in Acute Myeloid Leukemias and Myelodyplastic Syndromes"@en . . "We will characterize candidate suppressor genes from the region of chromosome-5q deletions in myeloid malignancies with particular focus on regulation of S mad5 expression and isolation of genes with distinct expression patterns in cells with del(5q). The project will lead to understanding of melecular basis of AML and MDS with the del(5q) and,consequently,to introducing novel diagnostic and therapeutic approaches."@en . . . . . . . "Bude provedena izolace a funk\u010Dn\u00ED charakterizace kandid\u00E1tn\u00EDch supresorov\u00FDch gen\u016F z oblasti delec\u00ED chromosomu-5q u myeloidn\u00EDch malignit. D\u016Fraz bude kladen na studium regulace exprese gen\u016F Smad5 a izolaci gen\u016F se zm\u011Bnami exprese v bu\u0148k\u00E1ch s del(5q). Projekt sm\u011B\u0159uje k pochopen\u00ED molekul\u00E1rn\u00ED podstaty akutn\u00ED myeloidn\u00ED leuk\u00E9mie a myelodysplastick\u00E9ho syndromu s del(5q) a k zaveden\u00ED nov\u00FDch diagnostick\u00FDch a l\u00E9\u010Debn\u00FDch postup\u016F." .