"2006-06-23+02:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NB7569"^^ . . "microdialysis" . . . . . . . . . . "Projekt je zam\u011B\u0159en na hodnocen\u00ED aktivity sympatick\u00E9ho nervov\u00E9ho syst\u00E9mu a zm\u011Bn jednotliv\u00FDch \u010D\u00E1st\u00ED metabolizmu katecholamin\u016F na lok\u00E1ln\u00ED \u00FArovni a za r\u016Fzn\u00FDch patologick\u00FDch situac\u00ED. Budou vy\u0161et\u0159ov\u00E1ny zdrav\u00E9 kontroly, pacienti s hyperkortizolismem, obezitou, Lok\u00E1ln\u00ED metabolizmus katecholamin\u016F v tukov\u00E9 tk\u00E1ni in vivo bude posuzov\u00E1n metodou mikrodial\u00FDzy, kter\u00E1 je ve sv\u011Bt\u011B u lid\u00ED b\u011B\u017En\u011B pou\u017E\u00EDv\u00E1na. Koncentrace katecholamin\u016F a jejich metabolit\u016F v mikrodialyz\u00E1tu reflektuj\u00ED jejich koncentrace tk\u00E1\u0148ov\u00E9. V\u00FDzkum zm\u011Bn funkce sympatick\u00E9ho nervov\u00E9ho syst\u00E9mu v tukov\u00E9 tk\u00E1ni ob\u00E9zn\u00EDch pacient\u016F a rozd\u00EDly oproti pacient\u016Fm s hyperkortizolismem p\u0159isp\u011Bj\u00ED k objasn\u011Bn\u00ED patogenezy trunk\u00E1ln\u00ED obezity u hyperkortizolismu. Tento probl\u00E9m nebyl dosud pln\u011B objasn\u011Bn. D\u00E1le budou studov\u00E1ny zm\u011Bny funkce sympatick\u00E9ho nervov\u00E9ho syst\u00E9mu vtukov\u00E9 tk\u00E1ni u hypertyre\u00F3zy a hypotyre\u00F3zy p\u0159ed a po l\u00E9\u010Db\u011B. Tyto zm\u011Bny rovn\u011B\u017E nebyly dosud pln\u011B charaketrizov\u00E1ny." . "The changes of sympathetic function in subcutaneous adipose tissue in endocrine diseaes. Understanding of pathogenesis and importance for clinical medicine"@en . . . "obesity" . . "10"^^ . . "10"^^ . "The aim of the project is to evaluate local activity of sympathetic nervous syst\u00E9m and specific changes in metabolism of catechols in the adipose tissue. The local sympathetic function will be evaluated using clinical microdialysis. Concentration of various substances in microdialysate reflects their concentrations in interstitial fluid. We will examine healthy controls and patients with obesity, chronic hypercortisolaemia, hyperthyroidism and hypothyroidism. The diferences in sympathetic function between patients with simple obesity and central obesity during chronic hypercortisolaemia give us an insight into mechanisms that are involved in development of typical central obesity. The characterization of specific changes in sympathetic function in adipose tisue of patients with hypothyroidism and hyperthyroidism has not been completely described so far and could explain some clinical symptoms."@en . . "Lok\u00E1ln\u00ED zm\u011Bny funkce sympatick\u00E9ho nervov\u00E9ho syst\u00E9mu v podko\u017En\u00ED tukov\u00E9 tk\u00E1ni u endokrinn\u00EDch onemocn\u011Bn\u00ED. Pochopen\u00ED patogeneze a v\u00FDznam pro l\u00E9\u010Dbu." . "sympathetic nervous system;adipose tissue;microdialysis;obesity;chronic hypercortisolaemia;hypothyroidism;hyperthyroidism"@en . "The changes in local sympathetic activity and lipolysis in subcutaneous fat tissue in patients with Cushing\u00B4s syndrome,obesity and thyroid function disturbances were evaluated. The changes in levels of selected adipocytokines were also described."@en . "adipose tissue" . "0"^^ . . "NB7569" . "Posoudili zm\u011Bny v lok\u00E1ln\u00ED aktivit\u011B sympatiku a lipol\u00FDze v podko\u017En\u00ED tukov\u00E9 tk\u00E1ni u Cushingova syndromu,obezity,poruch funkce \u0161t\u00EDtn\u00E9 \u017El\u00E1zy. Popsali zm\u011Bny n\u011Bkter\u00FDch adipocytokin\u016F u obezity a Cushingovy syndromu."@cs . "chronic hypercortisolaemia" . . "1"^^ . . . "1"^^ . "hypothyroidism" . "sympathetic nervous system" .