. . "http://www.isvav.cz/projectDetail.do?rowId=NB7099"^^ . "ghrelin;acromegaly;growth hormone;growth hormone deficiency;obesity;renal failure;malnutrition"@en . "NB7099" . . "13"^^ . "13"^^ . "Byly pops\u00E1ny zm\u011Bny sekrece ghrelinu za r\u016Fzn\u00FDch patologick\u00FDch stav\u016F,u malnutrice r\u016Fzn\u00E9 etiologie (ment\u00E1ln\u00ED anorexie a syndromu kr\u00E1tk\u00E9ho st\u0159eva),obezity,akromegalie,deficitu r\u016Fstov\u00E9ho hormonu v dosp\u011Blosti a ren\u00E1ln\u00ED insuficience."@cs . "acromegaly" . "obesity" . . . . . "Ghrelin is a new peptide hormone serving as a regulator of growth hormone secretion, food intake and nutritionalstatus. Its physiological presence in most tissue suggest the importance of ghrelin in this sites. The project will chracterize the physiological importance in petients with nutritional disordres. The patients with obesity, anorexia nervosa and malnutrition will be studied. The results could improve the therapy of some disorders. We will also study the changes of ghrelin plasma levels in acromegaly and growth hormone deficiency in relationship with other parametrs. The results could contribute to the improvment of diagnostic and therapeutis strategies. Finally, the project is dealing with the role of ghrelin in kidney and in pathogenesis of renal failure. Kidney belongs to the organs containing high amount of ghrelin. Therefore it could play substantial role in pathogenesis of kidney disorders."@en . "2006-06-23+02:00"^^ . . "Fyziologick\u00E1 role ghrelinu u \u010Dlov\u011Bka; v\u00FDznam pro klinickou medic\u00EDnu." . "0"^^ . "Physiological role of ghrelin; the importance for clinical medicine."@en . "ghrelin" . "1"^^ . . . "renal failure" . . . "0"^^ . . . "growth hormone deficiency" . "growth hormone" . "Ghrelin je nov\u00FDm hormonem pod\u00EDlej\u00EDc\u00EDm se na regulaci p\u0159\u00EDjmu potravy a nutri\u010Dn\u00EDho stavu organismu. Dal\u0161\u00ED jeho funkce jsou dosud neobjasn\u011Bny. Projekt je zam\u011B\u0159en ne jeho \u00FAlohu ve t\u0159ech z\u00E1kladn\u00EDch oblastech. Bude studov\u00E1na \u00FAloha ghrelinu v patogeneze obezity a posouzeny mo\u017Enosti stratifikace ob\u00E9zn\u00EDch pacient\u016F se z\u0159etelem k terapeutick\u00FDm postup\u016Fm. Bude studov\u00E1na \u00FAloha ghrelinu u manutrice a ment\u00E1ln\u00ED anorexie op\u011Bt se z\u0159etelem k mo\u017Enosti zlep\u0161en\u00ED terapie. D\u00E1le bude studov\u00E1no p\u016Fsoben\u00ED ghrelinu na sekreci r\u016Fstov\u00E9ho hormonu, u pacient\u016F s deficitem r\u016Fstov\u00E9ho hormonu a akromegali\u00ED. Op\u011Bt bude br\u00E1n z\u0159etel na n\u00E1vrh mo\u017En\u00E9ho diagnostick\u00E9ho a terapeutick\u00E9ho p\u016Fsoben\u00ED ghrelinu. Kone\u010Dn\u011B se projekt bude zab\u00FDvat zm\u011Bnami hladin ghrelinu v z\u00E1vislosti na stupni po\u0161kozen\u00ED ledvin s c\u00EDlem objasnit jeho \u00FAlohu v patogenezi re\u00E1ln\u00EDho psoti\u017Een\u00ED." . . "The changes in ghrelin secretion were described in following conditions: malnutrition of different aetiology (anorexia nervosa,short bowel syndrome),obesity,acromegaly,growth hormone deficiency in adults and renal failure."@en . . . . .