"http://www.isvav.cz/projectDetail.do?rowId=NB6822"^^ . "2004-07-12+02:00"^^ . "0"^^ . "Fatty acids" . . . "Cholesterol synthesis" . . "NB6822" . "LDL-apheresis" . "Prospective clinical study of the mutual interactions and particular role of fundamental lipid related atherogenic mechanisms in patients with familial hypercholesterolemia treated by low density lipoprotein apheresis. Project will investigate changes and correlation of the i) plasma and cell mambrane unsaturated and saturated fatty acids, ii) lipoperoxidation processes and antioxidant consumption, iii) cholesterol biosynthetic pathway and its intermediary products. The results might improve our knowledge and thus treatment of atherosclerosis, which is the leading cause of morbidity and mortality in Czech republic."@en . "Study of atherogenic mechanisms during treatment with LDL-apheresis: the role of fatty acid metabolism, cholesterol synthesis and lipoperoxidation"@en . . . "Atherosclerosis;Hyperlipidemia;LDL-apheresis;Cholesterol synthesis;Fatty acids;Lipoperoxidation"@en . "Prospektivn\u00ED klinick\u00E1 studie vz\u00E1jemn\u00E9 interakce a \u00FAlohy nejd\u016Fle\u017Eit\u011Bj\u0161\u00EDch lipidov\u00FDch aterogenn\u00EDch mechanism\u016F u pacient\u016F s famili\u00E1rn\u00ED hypercholesterol\u00E9mi\u00ED, l\u00E9\u010Den\u00FDch LDL (low density lipoprotein) afer\u00E9zou. Projekt bude zkoumat zm\u011Bny a korelace n\u00E1sleduj\u00EDc\u00EDch parametr\u016F: i) nenasycen\u00E9 a nasycen\u00E9 mastn\u00E9 kyseliny v plasm\u011B a bun\u011B\u010Dn\u00E9 membr\u00E1n\u011B, ii) pr\u016Fb\u011Bh lipoperoxidace a konsumpce antioxidant\u016F, iii) biosynt\u00E9za cholesterolu a jeho intermedi\u00E1rn\u00EDch produkt\u016F. Z\u00EDskan\u00E9 poznatky mohou p\u0159isp\u011Bt k objasn\u011Bn\u00ED a t\u00EDm i k l\u00E9\u010Db\u011B procesu ateroskler\u00F3zy, kter\u00E1 je nej\u010Dast\u011Bj\u0161\u00ED p\u0159\u00ED\u010Dinou morbidity a mortality v \u010Cesk\u00E9 republice." . . . . . "21"^^ . . . . "21"^^ . "0"^^ . "Atherosclerosis" . "Studium aterogenn\u00EDch mechanizm\u016F p\u0159i l\u00E9\u010Db\u011B LDL-afer\u00E9zou: \u00FAloha metobolizmu mastn\u00FDch kyselin, synt\u00E9zy cholesterolu a lipoperoxidace" . "Hyperlipidemia" . . . . . "1"^^ . "Studie prok\u00E1zala v\u00FDznamn\u00E9 poklesy nejen koncentrace cholesterolu v plasm\u011B a relevantn\u00EDch LP t\u0159\u00EDd\u00E1ch, ale i zm\u011Bny koncentrac\u00ED prekurzor\u016F cholesterolu, fytosterol\u016F a mastn\u00FDch kyselin. Pozorov\u00E1n byl pokles TBARS, beze zm\u011Bn koncentrace vitaminu E."@cs .