"degranulation" . " oxidative burst" . . " polyphenols" . "V\u00FDsledkem aktivace tk\u00E1\u0148ov\u00FDch a krevn\u00EDch fagocyt\u016F je produkce reaktivn\u00EDch metabolit\u016F kysl\u00EDku v pr\u016Fb\u011Bhu oxidativn\u00EDho stresu. Odpov\u011B\u010F profesion\u00E1ln\u00EDch fagocyt\u016F po jejich aktivaci m\u016F\u017Ee sni\u017Eovat cel\u00E1 \u0159ada l\u00E9\u010Div, l\u00E1tek p\u0159\u00EDrodn\u00EDho p\u016Fvodu a endogenn\u00EDch medi\u00E1tor\u016F. Bude pops\u00E1n \u00FA\u010Dinek nov\u011B syntetizovan\u00FDch deriv\u00E1t\u016F p\u0159\u00EDrodn\u00EDch l\u00E1tek ze skupiny polyfenol\u016F na mechanismus oxidativn\u00EDho vzplanut\u00ED profesion\u00E1ln\u00EDch fagocyt\u016F na bun\u011B\u010Dn\u00E9 a subcelul\u00E1rn\u00ED \u00FArovni s vyu\u017Eit\u00EDm modern\u00EDch metodick\u00FDch p\u0159\u00EDstup\u016F molekul\u00E1rn\u00ED biologie." . . "Molekul\u00E1rn\u011B-biologick\u00E9 aspekty farmakologick\u00E9ho ovlivn\u011Bn\u00ED aktivace profesion\u00E1ln\u00EDch fagocyt\u016F" . "2012-07-12+02:00"^^ . . "0"^^ . "2011-12-31+01:00"^^ . . "2011-03-02+01:00"^^ . "1"^^ . "MEB0810013" . . "3"^^ . . "0"^^ . "3"^^ . . . "Byly pops\u00E1ny \u00FA\u010Dinky vybran\u00FDch p\u0159\u00EDrodn\u00EDch l\u00E1tek, desti\u010Dkov\u00E9ho medi\u00E1toru serotoninu a agonist\u016F a antagonist\u016F histaminov\u00FDch receptor\u016F na tvorbu reaktivn\u00EDch metabolit\u016F kysl\u00EDku a dus\u00EDku fagocyty u zdrav\u00FDch jedinc\u016F i u potkan\u016F s indukovanou artritidou."@cs . . " phagocytes" . "Activation of tissue and blood phagocytes results in a production of reactive oxygen species during the oxidative stress. The response of professional phagocytes after their activation may be diminished by many drugs, natural compounds and endogenous mediators. The effects of newly synthetised derivatives of natural compounds of the polyphenolic group on the mechanism of oxidative burst of professional phagocytes on both cellular and subcellular level will be described using modern methodological approaches of molecular biology."@en . . " reactive oxygen species" . . . . . "Molecular biological perspectives of the pharmacological modulation of the activation of professional phagocytes"@en . . . . "Efects of selected natural compounds, platelet-derived serotonin and agonists/antagonists of histamine receptors on production of reactive oxygen and nitrogen species by phagocytes in healthy individuals and rats with induced arthritis were described."@en . . "http://www.isvav.cz/projectDetail.do?rowId=MEB0810013"^^ . "2010-01-01+01:00"^^ . "degranulation, phagocytes, oxidative burst, polyphenols, reactive oxygen species, serotonin"@en .