. . "glycosynthases" . "MEB020824" . . "2010-06-30+02:00"^^ . . . " glycoconjugates" . " mutagenesis" . . "2008-01-01+01:00"^^ . "2009-04-01+02:00"^^ . . "Unique furanose-containing glycoconjugates were prepared. Several of them showed an ability to increase the macrophage TNF-\u03B1 production. This property might be a basis for their future application as a vaccines against serious deseases."@en . . " glycosidic bonds" . "C\u00EDlem projektu je z\u00EDskat pomoc\u00ED c\u00EDlen\u00E9 mutagenese mikrobi\u00E1ln\u00ED galaktosynthasu, je\u017E by byla schopna katalyzovat transglykosylaci donor\u016F p\u0159ipraven\u00FDch chemickou synt\u00E9zou. T\u00EDmto zp\u016Fsobem z\u00EDskat konjug\u00E1ty obsahuj\u00EDc\u00ED furanosu, kter\u00E9 by byly vhodn\u00E9 pro farmaceutick\u00E9 \u00FA\u010Dely." . " transglycosylation" . . . . . "2009-12-31+01:00"^^ . . " furanose" . "The aim of this project is obtaining by mutagenesis microbial galactosynthase that will be able to catalyse transglycosylation of donors prepared by chemical synthesis. Thus obtain new glycoconjugates with furanose suitable for pharmaceutical use."@en . . . . "Byly p\u0159ipraveny neobvykl\u00E9 glykokonjug\u00E1ty se sacharidy furanosov\u00E9ho typu. N\u011Bkter\u00E9 z\u00A0p\u0159ipraven\u00FDch glykokonjug\u00E1t\u016F prokazovaly schopnost zvy\u0161ovat makrofagovou produkci TNF-\u03B1. Tato vlastnost by mohla b\u00FDt v\u00A0budoucnu podstatou jejich vyu\u017Eit\u00ED jako sou\u010D\u00E1st vakc\u00EDn proti z\u00E1va\u017En\u00FDm chorob\u00E1m."@cs . "0"^^ . "http://www.isvav.cz/projectDetail.do?rowId=MEB020824"^^ . . " regioselectivity" . . "1"^^ . . "New glycosynthases and their use in glycoconjugates synthesis"@en . "glycosynthases; glycoconjugates; transglycosylation; glycosidic bonds; stereoselectivity; regioselectivity; mutagenesis; furanose; pharmaceutical use"@en . "2"^^ . "0"^^ . "Nov\u00E9 glykosynthasy a jejich vyu\u017Eit\u00ED pro synt\u00E9zu glykokonjug\u00E1t\u016F" . "2"^^ . " stereoselectivity" .