. . . "2010-05-01+02:00"^^ . "2012-12-31+01:00"^^ . . " microtubules" . "Nucleus" . " tubulin" . " nuclear export sequences" . "Transport tubulinu mezi j\u00E1drem a cytoplazmou" . "Nucleus; nuclear transport; nuclear export sequences; tubulin; microtubules; plant"@en . "Nucleocytoplasmic transport of tubulin"@en . . . . . . " nuclear transport" . . . "2013-06-28+02:00"^^ . . . "The goal of this project is to demonstrate and to explain the function of nuclear export sequences in tubulin molecules in eukaryotic cells. Possible specific or conserved functions of nuclear export sequences in plant and animal tubulins will be studied. Further, the role of nuclear export of plant tubulin in growth end development of plant organism will be studied."@en . . "1"^^ . "0"^^ . "1"^^ . . "2012-02-16+01:00"^^ . "Nuclear export sequences in alpha- and beta-tubulin were tested in animal and plant model system. Functional NES were mutated. The expression of mutated beta-tubulin affected the cell cycle progress in tobacco cells. The inhibition of nuclear export resulted in tubulin accumulation in tobacco nuclei."@en . "1"^^ . . "Prok\u00E1zat a objasnit v\u00FDznam jadern\u00FDch exportn\u00EDch sekvenc\u00ED v molekul\u00E1ch tubulin\u016F v eukaryotick\u00FDch bu\u0148k\u00E1ch, jejich p\u0159\u00EDpadnou specifickou roli v bu\u0148k\u00E1ch rostlinn\u00FDch a v\u00FDznam pro r\u016Fst a v\u00FDvoj rostlinn\u00E9ho organismu." . . "0"^^ . . "ME10103" . "http://www.isvav.cz/projectDetail.do?rowId=ME10103"^^ . . "Byly identifikov\u00E1ny konzervovan\u00E9 jadern\u00E9 exportn\u00ED sekvence (NES) v alfa- i beta-tubulinu. Funk\u010Dnost sekvenc\u00ED byla testov\u00E1na testem na jadern\u00FD export v \u017Eivo\u010Di\u0161n\u00E9m i rostlinn\u00E9m modelov\u00E9m syst\u00E9mu. Funk\u010Dn\u00ED NES v molekule beta-tubulinu byly mutov\u00E1ny. Exprese mutovan\u00E9ho tubulinu ovlivnila pr\u016Fchod bun\u011B\u010Dn\u00FDm cyklem. O\u0161et\u0159en\u00ED bun\u011Bk inhibitorem jadern\u00E9ho exportu indukovalo hromad\u011Bn\u00ED tubulinu v j\u00E1drech."@cs . .