"0"^^ . "2013-06-28+02:00"^^ . . "2010-05-01+02:00"^^ . "proteomics; intraamniotic inflammation; amniotic fluid"@en . . . "1"^^ . "S vyu\u017Eit\u00EDm glob\u00E1ln\u00EDch proteomick\u00FDch a c\u00EDlen\u00FDch anal\u00FDz jsme u pacientek se spont\u00E1nn\u00EDm p\u0159ed\u010Dasn\u00FDm porodem mezi 24. a 37. t\u00FDdnem t\u011Bhotenstv\u00ED charakterizovali zm\u011Bny v proteomu plodov\u00E9 vody z konce prvn\u00ED doby porodn\u00ED, ke kter\u00FDm doch\u00E1z\u00ED na podklad\u011B mikrobi\u00E1ln\u00ED invaze do amni\u00E1ln\u00ED dutiny a histologick\u00E9 chorioamnionitidy."@cs . "1"^^ . "ME10025" . . . "With using unbiased and hypothesis-driven approaches, we analyzed amniotic fluid obtained at the end of the first stage of from women with spontaneous preterm birth between gestational ages 24 and 37 weeks to characterize proteome-wide changes associated with microbial invasion of the amniotic cavity and histological chorioamnionitis."@en . " intraamniotic inflammation" . "5"^^ . . . "5"^^ . . "Intraamniotic inflammation has been demonstrated to be associated with a significantly increased rate of neonatal adverse outcome, even in the absence of demonstrable positive cultures. The biochemical and protein composition of amniotic fluid is altered during pregnancy and reflects both physiological as well as pathological changes in the fetomaternal compartment. Modern proteomic technologies are able to detect and characterize even the slightest changes in protein composition of various biological matrices. In the proposed project, we are going to use a combination of multidimensional liquid chromatography separation with subsequent tandem mass spectrometric analyzes. Thanks to the ability to both identify and quantify a large number of proteins, this approach seems to be a very promising one for the detection of changes in amniotic fluid protein composition. Characterization of the human AF proteome represents a crucial step toward the subsequent study of aberrant protein expression and the ide"@en . "Proteomick\u00E1 identifikace biomarker\u016F intraamni\u00E1ln\u00EDho z\u00E1n\u011Btu v plodov\u00E9 vod\u011B pacientek se spont\u00E1nn\u00EDm p\u0159ed\u010Dasn\u00FDm porodem" . . . . "http://www.isvav.cz/projectDetail.do?rowId=ME10025"^^ . . "Prim\u00E1rn\u00EDm c\u00EDlem projektu je pomoc\u00ED modern\u00EDch n\u00E1stroj\u016F proteomiky charakterizovat rozd\u00EDly v proteinov\u00FDm slo\u017Een\u00EDm plodov\u00E9 vody u pacientek se spont\u00E1nn\u00EDm p\u0159ed\u010Dasn\u00FDm porodem v gesta\u010Dn\u00EDm st\u00E1\u0159\u00ED mezi 24+0 a\u017E 36+6 s p\u0159\u00EDtomnosti \u010Di absenc\u00ED intraamni\u00E1ln\u00EDho z\u00E1n\u011Btu." . . . "2012-02-16+01:00"^^ . "2012-12-31+01:00"^^ . . . . . "Proteomic identification of biomarkers of intraamniotic inflammation in amniotic fluid in preterm birth patients"@en . "proteomics" . .