"Z\u00E1kladn\u00EDm c\u00EDlem projektu je zefektivn\u011Bn\u00ED v\u00FDzkumu nov\u00FDch biologicky aktivn\u00EDch l\u00E1tek. Poznatky dosa\u017Een\u00E9 \u0159e\u0161en\u00EDm projektu budou zahrnovat v\u00FDsledky v\u00FDzkumu metodiky p\u0159\u00EDpravy t\u011Bchto l\u00E1tek a v\u00FDsledky jejich protin\u00E1dorov\u00E9 aktivity a p\u016Fsoben\u00ED na bun\u011B\u010Dn\u00FD cyklus." . " solid phase synthesis" . "2012-12-31+01:00"^^ . . "synthesis" . . "2013-06-28+02:00"^^ . . . "In 2012 the research was focused on preparation of chemical libraries of biologically active compounds and on advanced testing of biological activity."@en . " anticancer activity" . "2009-04-01+02:00"^^ . "V\u00FDzkum nov\u00FDch slou\u010Denin s protin\u00E1dorovou aktivitou za pomoci kombinatori\u00E1ln\u00ED chemie" . . "V roce 2012 byla pozornost v\u011Bnov\u00E1na p\u0159\u00EDprav\u011B dal\u0161\u00EDch chemick\u00FDch knihoven biologicky aktivn\u00EDch slou\u010Denin a d\u00E1le pokro\u010Dil\u00E9mu testov\u00E1n\u00ED biologick\u00E9 aktivity."@cs . "0"^^ . "0"^^ . "1"^^ . " combinatorial chemistry" . . "ME09057" . . . . "Research of new organic compounds with anticancer activity with use of combinatorial chemistry"@en . . "http://www.isvav.cz/projectDetail.do?rowId=ME09057"^^ . . . "2012-02-23+01:00"^^ . . "synthesis; solid phase synthesis; combinatorial chemistry; anticancer activity; enzyme inhibition"@en . "16"^^ . "The principal aim of this project is to accelerate the early stages of the drug discovery process, in particular identification of novel compounds possessing relevant pharmacological properties. In order to achieve our goal, the project combines (i) development of synthetic routes to access novel biologically active compounds, (ii) application of combinatorial chemistry methods to provide access to large number of their derivatives, (iii) and biological testing in vitro. Close collaboration between institutions with proven record in their respective research areas will reduce the time needed for discovery of promising biologically active compounds and, in the most ambitious scenario, lead to discovery of a new drug. The subject of this research proposal is to expand the existing collaboration in the area of drug discovery, particularly in the search for new heterocyclic compounds possessing pharmacologically relevant properties, between Department of Organic Chemistry, Palacky University, Olomouc, a"@en . . "16"^^ . . . . . .