. "Theoretical investigation of RNA structure, dynamics and function and their relationship."@en . . "(1) Finding new information about structure, dynamics and function of small RNA molecules (e.g. RNA aptamers, riboswitches) by applying methods of computational chemistry in close collaboration with experts from CU Boulder (e.g. experimentalist Mike Yarus and bioinformatist Rob Knight). (2) Characterization of binding sites (example: tryptophan aptamer) and design of new, fully functional structures. (3) Characterization of free and bound form of riboswitches and the conformational changes caused by ligand binding (example: SAM riboswitch)."@en . . . . . . "RNA aptamers" . " molecular machines and switches" . "ME09019" . . "0"^^ . "3"^^ . " computer simulations" . "0"^^ . "RNA aptamers; riboswitches; molecular machines and switches; computer simulations; molecular dynamics"@en . . "3"^^ . "1"^^ . . . . "2013-06-28+02:00"^^ . "In 2012, we continued to study the RNA aptamers. Namely, we performed molecular modeling of the TRP and HIS aptamers. The predicted ligand:aptamer complex structures and calculated binding affinities were then compared to experimental results. We also started the molecular modeling investigation of the hammerhead ribozyme. Results of this project were published in RNA and at conferencies."@en . . . . . "V roce 2012 jsme pokra\u010Dovali ve studiu RNA aptamer\u016F, konkr\u00E9tn\u011B v modelov\u00E1n\u00ED TRP a HIS aptamer\u016F. Navr\u017Eenou strukturu komplexu ligand:aptamer a vypo\u010Dten\u00E9 vazebn\u00E9 konstanty jsme n\u00E1sledn\u011B porovnali s experiment\u00E1ln\u00EDmi \u00FAdaji. Zah\u00E1jili jsme tak\u00E9 teoretick\u00E9 studium hammerhead ribozymu. Dosa\u017Een\u00E9 v\u00FDsledky jsme prezentovali na mezin\u00E1rodn\u00EDch konferenc\u00EDch a publikovali v \u010Dasopise %22RNA%22."@cs . "(1) Z\u00EDsk\u00E1n\u00ED nov\u00FDch poznatk\u016F o struktu\u0159e, dynamice a funkci RNA molekul pomoc\u00ED molekulov\u00E9ho modelov\u00E1n\u00ED. (2) Charakterizace vazebn\u00E9ho m\u00EDsta v RNA aptamerech, nap\u0159. tryptophan aptameru. Design a p\u0159\u00EDprava nov\u00FDch pln\u011B funk\u010Dn\u00EDch aptamer\u016F." . . . "Teoretick\u00E9 studium struktury, dynamiky a funkce RNA a jejich vz\u00E1jemn\u00FDch vztah\u016F" . . . " riboswitches" . "2012-12-31+01:00"^^ . "2009-04-01+02:00"^^ . "2012-02-23+01:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=ME09019"^^ .