. . . "Hlavn\u00EDm c\u00EDlem projektu bude snaha o celkovou charakterizaci nov\u00E9 rodiny WrbA protein\u016F na molekul\u00E1rn\u00ED \u00FArovni a v\u00FDzkum biologick\u00E9 funkce t\u011Bchto protein\u016F." . "2013-06-28+02:00"^^ . . " bacterial flavodoxins" . . "2012-02-23+01:00"^^ . . . "The role of WrbA protein in life"@en . . "The project was focused on general characterization of a new family of WrbA proteins on molecular level as well as at description of their unknown biological function. Basic on successful solving of particular aims is possible to state that the project was solved with big scientific success. The results were published in 6 publications."@en . . . . "2012-12-31+01:00"^^ . . "1"^^ . " multimeric flavoproteins" . "Hlavn\u00EDm c\u00EDlem projektu byla snaha o celkovou charakterizaci nov\u00E9 rodiny WrbA protein\u016F na molekul\u00E1rn\u00ED \u00FArovni a v\u00FDzkum biologick\u00E9 funkce t\u011Bchto protein\u016F. Na z\u00E1klad\u011B \u00FAsp\u011B\u0161n\u00E9ho \u0159e\u0161en\u00ED d\u00EDl\u010D\u00EDch c\u00EDl\u016F projektu se poda\u0159ilo hlavn\u00ED c\u00EDl projektu naplnit. V\u00FDsledky byly publikov\u00E1ny v 6 publikac\u00EDch."@cs . "0"^^ . "4"^^ . "4"^^ . "2009-04-01+02:00"^^ . "0"^^ . . . . . "WrbA protein of E.coli; multimeric flavoproteins; bacterial flavodoxins; eukaryotic NAD(P)H:quinone oxidoreductases"@en . "\u00DAloha proteinu WrbA v \u017Eivot\u011B" . "ME09016" . "WrbA protein of E.coli" . . "http://www.isvav.cz/projectDetail.do?rowId=ME09016"^^ . . . . "The objective of the proposed work is to understand the relationship between structure and function for the E. coli protein WrbA, the founding member of a widespread and highly conserved family of proteins. Although WrbA is related to the well-studied bacterial FMN-dependent flavodoxin electron carriers and eukaryotic FAD-dependent oxidoreductases, it presents significant distinctions from both, and has a completely unknown physiological role. The very wide phylogenetic distribution of WrbA homologs suggests an important metabolic role that may reveal unexpected evolutionary and ecological relationships among distant organisms. New hypotheses that follow from our previous work on WrbA structures will be evaluated in a comparative structure/function framework with its better-understood relatives. The aims are related to our long-term interests in the molecular origins of intramolecular structural organization, stability, and dynamics, and of intermolecular affinity, specificity, and cooperativity. The"@en .