. "ME08008" . . "The goals and expected results of the proposed project are directed to the field of studies on lectins from pathogens that are involved in the host cell recognition and binding, which may further result in invasion. In the first period of the research, we will focus our attention on bacterial lectins, mostly those from opportunistic pathogens, which are dangerous mainly for immunocompromised patients. In the second period, we will extend our studies also on viruses. Our goals will be not only to characterize the above interaction from the structure and function point of view, but mainly to design molecules that will \u201Cinhibit\u201D these lectins and will, therefore, exhibit pharmacological effects. Within this direction, the main tool will be theoretical methods, essentially docking and sophisticated database search in libraries of existing compounds. Also in silico methods development within this direction will be included."@en . . . "http://www.isvav.cz/projectDetail.do?rowId=ME08008"^^ . " pathogens" . "0"^^ . " X-ray structure" . . . "2012-02-16+01:00"^^ . "0"^^ . "2013-06-28+02:00"^^ . "1"^^ . . . . "2008-01-01+01:00"^^ . . . . . "2012-12-31+01:00"^^ . "Saccharides carry enormous information potential that is much wider compared to other biomolecules. Proteins that bind saccharides with high specificity are called lectins. These are involved in many key biological processes. In the framework of this project, we have prepared and characterized several lectins by measuring their affinity to selected saccharides."@en . "Sacharidy nesou enormn\u00ED informa\u010Dn\u00ED potenci\u00E1l, mnohon\u00E1sobn\u011B v\u011Bt\u0161\u00ED ne\u017E jin\u00E9 typy biomolekul. Proteiny specificky v\u00E1zaj\u00EDc\u00ED sacharidy se naz\u00FDvaj\u00ED lektiny. Ty se \u00FA\u010Dastn\u00ED mnoha kl\u00ED\u010Dov\u00FDch fyziologick\u00FDch proces\u016F. V r\u00E1mci projektu jsme p\u0159ipravili n\u011Bkolik lektin\u016F a m\u011B\u0159ili s\u00EDlu jejich interakce s cukry. Proces interakce jsme modelovali teoretick\u00FDmi metodami, kter\u00E9 jsme t\u00E9\u017E vyv\u00EDjeli."@cs . " biomolecular interactions" . . "C\u00EDlem projektu je strukturn\u011B-funk\u010Dn\u00ED charakterizace interakc\u00ED lektin\u016F z patogenn\u00EDch organism\u016F a n\u00E1vrh \u201Einhibitor\u016F\u201C t\u011Bchto lektin\u016F s potenci\u00E1ln\u00EDmi farmakologick\u00FDmi \u00FA\u010Dinky." . . "lectins" . "N\u00E1vrh antibakteri\u00E1ln\u00EDch a antivirov\u00FDch l\u00E9k\u016F na b\u00E1zi cukr\u016F a glykomimetik" . "Design of Carbohydrates and Glycomimetics as Antibacterial and Antiviral Drugs"@en . "lectins; pathogens; biomolecular interactions; X-ray structure; docking; molecular modelling"@en . . " docking" . . . "43"^^ . "43"^^ . .