. "autoimmune polyglandular syndrom; genetic predisposition; Th1/Th2-balance"@en . "http://www.isvav.cz/projectDetail.do?rowId=ME 375"^^ . . "It is the goal of the submitted project to investigate a possible link of genetic predisposition and immunological features in autoimmune polyglandular syndromes (APS). One important question is whether or not clinically silent and overt forms of APS canbe differentiated by their genetic predisposition. The immunological studies will focus on both B- and T-cell mediated autoimmune responses. A broad range of recombinant antigens that were generated at IPM, Hamburg, can be used for a sensitive and specific diagnosis of APS. Because the T-cell mediated autoimmune response is crucial for the pathogenesis of APS the recombinant proteins also can be used for detection of autoreactive T-cells and the Th1/Th2-balance can be determined by ultrasensitive RT-PCR. Eventually, the specific detection of autoreactive T cells might have a great impact on future treatment of the autoimmune disease already in the subclinical state."@en . . . " genetic predisposition" . "Molecular characterization of autoimmune polyglandular syndromes"@en . "Molekul\u00E1rn\u00ED charakteristika autoimunitn\u00EDho poplyglandul\u00E1ln\u00EDho syndromu" . "2009-05-22+02:00"^^ . . "autoimmune polyglandular syndrom" . . . "1"^^ . "0"^^ . . "1"^^ . . . . . "1"^^ . . "C\u00EDlem p\u0159edlo\u017Een\u00E9ho projektu je zjistit mo\u017Enou vazbu mezi genedickou predizpozic\u00ED a rozvojem imunopatologick\u00FDch znak\u016F u autoimunitn\u00EDho polyglandul\u00E1rn\u00EDho syndromu (APS). Jednou z hlavn\u00EDch ot\u00E1zek je zda klinicky rozvinut\u00FD a nerozvinut\u00FD APS m\u016F\u017Ee m\u00EDt odli\u0161nosti v genetick\u00E9 predizpozici. Imunologick\u00E9 studie se zam\u011B\u0159\u00ED na v\u00FDznam B a T lymfocyt\u016F v autoimunitn\u00EDm procesu." . . . . "Exprese HLA antigen\u016F ukazuje na genetickou rozd\u00EDlnost mezi izolovanou autoimunitn\u00ED tyreoiditidou a ob\u011Bma skupinami s polyglandul\u00E1rn\u00EDmi projevy."@cs . . "0"^^ . . "ME 375" .