. "cancer, tumors, cytostatics, platinum, cisplatin, DNA"@en . "V\u00FDsledkem bylo pozn\u00E1n\u00ED n\u011Bkter\u00FDch podrobnost\u00ED mechanism\u016F, kter\u00FDm vybran\u00E9 komplexy platiny realizuj\u00ED protin\u00E1dorov\u00FD efekt."@cs . . . "Interakce DNA s polynukle\u00E1rn\u00EDmi komplexy platiny" . "cancer" . . " cytostatics" . "Dinuclear and trinuclear platinum complexes represent a novel class of antitumor compounds. The development of polynuclear platinum complexes is based on a hypothesis that a change of their DNA binding mode, in comparison with cisplatin, can affect their antitumor efficiency. Confirmation of this hypothesis requires detailed knowledge of conformational alterations induced in DNA by dinuclear and trinuclear platinum complexes. This joint project has been proposed on the basis of mutual interest to understand how agents damaging DNA exhibit their effects on the level of DNA. Specific goals of this project are to prepare specific adducts of dinuclear and trinuclear platinum complexes in predetermined sequences of DNA and to systematically investigate these adducts from the viewpoint of consequences of their formation for DNA conformation."@en . "DNA interactions of polynuclear platinum"@en . "0"^^ . . "Dinukle\u00E1rn\u00ED a trinukle\u00E1rn\u00ED komplexy platiny p\u0159edstavuj\u00ED novou t\u0159\u00EDdu protin\u00E1dorov\u011B \u00FA\u010Dinn\u00FDch slou\u010Denin. V\u00FDvoj polynukle\u00E1rn\u00EDch komplex\u016F platiny je zalo\u017Een na hypot\u00E9ze, podle kter\u00E9 zm\u011Bna zp\u016Fsobu vazby komplexu k DNA m\u016F\u017Ee, ve srovn\u00E1n\u00ED s cisplatinou, zm\u011Bnit jeho protin\u00E1dorovou \u00FA\u010Dinnost. Potvrzen\u00ED t\u00E9to hypot\u00E9zy vy\u017Eaduje podrobn\u00E9 znalosti o konforma\u010Dn\u00EDch zm\u011Bn\u00E1ch vyvolan\u00FDch v DNA dinukle\u00E1rn\u00EDmi a trinukle\u00E1rn\u00EDmi komplexy platiny. Tento spole\u010Dn\u00FD projekt vznikl na z\u00E1klad\u011B vz\u00E1jemn\u00E9ho z\u00E1jmu porozum\u011Bt tomu, jak\u00FDm zp\u016Fsobem agens po\u0161kozuj\u00EDc\u00ED DNA realizuj\u00ED sv\u00E9 efekty pr\u00E1v\u011B na \u00FArovni DNA. Specifick\u00E9 c\u00EDle tohoto projektu jsou p\u0159ipravit specifick\u00E9 adukty dinukle\u00E1rn\u00EDch a trinukle\u00E1rn\u00EDch komplex\u016F platiny v p\u0159edem zvolen\u00FDch sekvenc\u00EDch DNA a tyto systematicky zkoumat z hlediska d\u016Fsledku jejich vzniku pro strukturu a konformaci DNA." . . . "1"^^ . " platinum" . . . . . " tumors" . "3"^^ . . "0"^^ . "ME 152" . "3"^^ . . " cisplatin" . . . "http://www.isvav.cz/projectDetail.do?rowId=ME 152"^^ . .