. . . . "Cardiovascular diseases are responsible for more than 50% of mortality in industrial countries. Therefore, the study of causes of these diseases belongs to the priority of biomedical research.The roots of cardiovascular diseases can be traced back to early ontogeny. The wordl specificity of CECR will be therefore the orientation on the developmental principles participating in the pathogeny of cardiovascular diseases.The long-term goal of this project is to create the center for the research of theoretical basis of prevention and therapy of ischemic heart disease, atherosclerosis, arterial and pulmonary hypertension.Results should contribute to the elucidation of mechanisms participating in the development of the risk factors (atherosclerosis, hypertension) and to characterization of their relationship to ischemic myocardial damage at various stages of ontogeny."@en . . . . "88"^^ . "Choroby srdce a c\u00E9v p\u0159edstavuj\u00ED nejz\u00E1va\u017En\u011Bj\u0161\u00ED onemocn\u011Bn\u00ED sou\u010Dasn\u00E9 doby, nebo\u0165 jsou p\u0159\u00ED\u010Dinou v\u00EDce jak 50% v\u0161ech \u00FAmrt\u00ED. Studium p\u0159\u00ED\u010Din vzniku t\u011Bchto onemocn\u011Bn\u00ED pat\u0159\u00ED proto k nesporn\u00FDm priorit\u00E1m biomedic\u00EDnsk\u00E9ho v\u00FDzkumu.P\u0159\u00ED\u010Diny vzniku z\u00E1va\u017En\u00FDch kardiovaskul\u00E1rn\u00EDch onemocn\u011Bn\u00ED je t\u0159eba hledat v \u010Dasn\u00FDch f\u00E1z\u00EDch ontogenetick\u00E9ho v\u00FDvoje. Sv\u011Btovou specifikou centra bude proto orientace na v\u00FDvojov\u00E9 principy, uplat\u0148uj\u00EDc\u00ED se v patogeneze t\u011Bchto chorob.C\u00EDlem je vytvo\u0159it centrum pro v\u00FDzkum teoretick\u00FDch z\u00E1klad\u016F prevence a terapie ischemick\u00E9 choroby srde\u010Dn\u00ED, atherosklerozy, syst\u00E9mov\u00E9 a plicn\u00ED hypertenze.Dosa\u017Een\u00E9 v\u00FDsledky p\u0159isp\u011Bj\u00ED k objasn\u011Bn\u00ED mechanism\u016F pod\u00EDlej\u00EDc\u00EDch se na v\u00FDvoji rizikov\u00FDch faktor\u016F (aterosklerozy a hypertenze) ve vztahu k vzniku ischemick\u00E9ho po\u0161kozen\u00ED srde\u010Dn\u00EDho svalu. M\u011Bly by b\u00FDt vyu\u017Eity p\u0159i racion\u00E1ln\u00ED prevenci a terapii t\u011Bchto chorob." . . "88"^^ . " myocardial protection" . . "Centrum soust\u0159edilo kapacity mezin\u00E1rodn\u011B uzn\u00E1van\u00FDch pracovi\u0161\u0165 na v\u00FDzkum teoretick\u00FDch z\u00E1klad\u016F nejz\u00E1va\u017En\u011Bj\u0161\u00EDho onemocn\u011Bn\u00ED sou\u010Dasn\u00E9 doby-ischemick\u00E9 choroby srde\u010Dn\u00ED. To umo\u017Enilo vznik prioritn\u00EDch v\u00FDsledk\u016F, kter\u00E9 by bez existence centra nebyly realizovateln\u00E9"@cs . . "http://www.isvav.cz/projectDetail.do?rowId=LN00A069"^^ . . " gender differences" . . "LN00A069" . . "ischemic heart disease" . . " hypertension prevention" . " gene analysis" . "Centrum experiment\u00E1ln\u00EDho v\u00FDzkumu chorob srdce a c\u00E9v" . "Center for experimental research of cardiovascular diseases"@en . "1"^^ . " endothelium" . "2"^^ . " atherosclerosis" . . "0"^^ . "2008-05-28+02:00"^^ . . " ontogenetic aspects" . "ischemic heart disease; arterial and pulmonary hypertension; atherosclerosis; gender differences; ontogenetic aspects; myocardial protection; hypertension prevention; gene analysis; endothelium; vascular smooth muscle cells"@en . "Centre concentrated the effort of internationally recognized laboratories on basic research of the most serious disease of modern time-ischemic heart disease. This facilitated the publication of original results which would be impossible without the exi"@en . . . " arterial and pulmonary hypertension" . .