"1"^^ . . . . "2"^^ . . . . "0"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=LN00A033"^^ . . . "53"^^ . "53"^^ . " proteome" . "Proteomov\u00E9 centrum pro studium intracelul\u00E1rn\u00EDho parazitizmu bakteri\u00ED" . . . " virulence factors" . . . "intracellular parasitism; proteome; intracellular bacteria; virulence factors; cytokines; CD markers; cellular organelles; gene expression"@en . . . . "To establish the center for proteome studies capable to analyze complex processes leading to serious up to now therapeutically uncontrolled human diseases. To prepare educational interdisciplinary facility for complex modern laboratory technologies.The proteome study of intracellular pathogens with the aim to find microbial markers suitable for diagnostics, markers associated with microbial invasiveness and virulance and, furthermore, to identify microbial immunoreactive components.The study of molecular interactions occurring in the early phase of infection of eucaryotic cells and whole organisms in order to get better understanding of the basis of intracellular parasitism and to find new prophylactic and therapeutic strategies."@en . . . " cellular organelles" . "Vytvo\u0159it centrum proteomov\u00FDch studi\u00ED schopn\u00E9 analyzovat slo\u017Eit\u00E9 procesy vedouc\u00ED k z\u00E1va\u017En\u00FDm dosud terapeuticky nezvl\u00E1dnut\u00FDm onemocn\u011Bn\u00EDm \u010Dlov\u011Bka. P\u0159ipravit \u0161kol\u00EDc\u00ED mezioborov\u00E9 pracovi\u0161t\u011B pro komplexn\u00ED, modern\u00ED, laboratorn\u00ED technologie.Proteomov\u00E1 anal\u00FDza intracelul\u00E1rn\u00EDch bakteri\u00E1ln\u00EDch patogen\u016F s c\u00EDlem nal\u00E9zt takov\u00E9 znaky mikrob\u016F, kter\u00E9 jsou vyu\u017Eiteln\u00E9 k jejich diagnostice, maj\u00ED vztah k jejich invazivit\u011B a virulenci a d\u00E1le identifikovat jejich imunoreaktivn\u00ED slo\u017Eky.Studium molekul\u00E1rn\u00EDch interakc\u00ED v pr\u016Fb\u011Bhu \u010Dasn\u00E9 f\u00E1ze infekce eukaryotick\u00FDch bun\u011Bk a organizm\u016F pro pochopen\u00ED podstaty intracelul\u00E1rn\u00EDho parazitizmu a nalezen\u00ED profylaktick\u00E9 a terapeutick\u00E9 strategie." . "2008-05-28+02:00"^^ . . "LN00A033" . " CD markers" . "intracellular parasitism" . "V\u00FDsledky za projekt Proteomov\u00E9 centrum zahrnuj\u00ED identifikaci protein\u016F specifick\u00FDch pro jednotliv\u00E9 subtypy intracelul\u00E1rn\u00EDho patogena F. tularensis li\u0161\u00EDc\u00ED se virulenc\u00ED, vytvo\u0159en\u00ED datab\u00E1ze imunoreaktivn\u00EDch protein\u016F a \u00FAdaje o modulaci sign\u00E1ln\u00EDch cest a geno"@cs . "The proteome center for the study of intracellular parasitism of microbes"@en . . "The results obtained from the project Proteome Center involve identification of proteins that distinguish subtypes F. tularensis differing in virulence, the formation of immunoreactive protein database and showing modulation of signaling pathways and gen"@en . " cytokines" . . " intracellular bacteria" .