. "C\u00EDlem projektu je objasnit molekul\u00E1rn\u00ED podstatu kl\u00ED\u010Dov\u00FDch mechanism\u016F reguluj\u00EDc\u00EDch imunitn\u00ED reakce za norm\u00E1ln\u00EDch a patologick\u00FDch okolnost\u00ED, a to p\u0159edev\u0161\u00EDm pomoc\u00ED z\u00E1kladn\u00EDho v\u00FDzkumu zam\u011B\u0159en\u00E9ho na receptory lymfocyt\u016F pro antigeny,n\u011Bkter\u00E9 cytokiny a hormony a Fc-receptory. Tento v\u00FDzkum bude zalo\u017Een na hypot\u00E9ze o kl\u00ED\u010Dov\u00E9 roli supramolekul\u00E1rn\u00ED (dom\u00E9nov\u00E9) organizace bun\u011B\u010Dn\u00E9 membr\u00E1ny a interakci imunoreceptor\u016F s cytoskeletem. Vzhledem k z\u00E1sadn\u00EDfyziologick\u00E9 d\u016Fle\u017Eitosti zkouman\u00FDch proces\u016F p\u0159edpokl\u00E1d\u00E1me, \u017Ee v\u00FDsledky na\u0161eho z\u00E1kladn\u00EDho v\u00FDzkumu budou solidn\u00EDm z\u00E1kladem pro v\u00FDvoj l\u00E1tek a postup\u016F vhodn\u00FDch pro praktick\u00E9 aplikace v diagnostice a terapii z\u00E1va\u017En\u00FDch imunopatologick\u00FDchporuch (nap\u0159. alergie a jin\u00E9 hypersensitivity, autoimunitn\u00ED a n\u011Bkter\u00E1 lymfoproliferativn\u00ED onemocn\u011Bn\u00ED)." . . . . "106"^^ . . "106"^^ . . . . . . . . "2008-05-28+02:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=LN00A026"^^ . . " cytokines" . . "1"^^ . . . " cytoskeleton" . "1"^^ . . "Bylo objeveno n\u011Bkolik nov\u00FDch molekul, kter\u00E9 hraj\u00ED roli jak v imunitn\u00ED odpov\u011Bdi a v patologick\u00FDch alergick\u00FDch reakc\u00EDch a objasn\u011Bny mechanismy zodpov\u011Bdn\u00E9 za odhojov\u00E1n\u00ED transplant\u00E1t\u016F o\u010Dn\u00ED rohovky. V\u00FDsledky budou z\u00E1kladem pro praktick\u00E9 aplikace v diagnostic"@cs . "Centrum molekul\u00E1rn\u00ED a bun\u011B\u010Dn\u00E9 imunologie" . "We discovered several new molecules playing roles in immune response and in pathological allergic reactions, and elucidated mechanisms responsible for rejection of corneal transplants. The results will serve for practical applications in diagnostics and"@en . "The aim of the project is to elucidate molecular basis of key mechanisms regulating immune reactions under normal and pathological conditions, by means of basic research of lymphocyte antigen-specific receptors, receptors of certaincytokines and hormones and Fc-receptors. This research will be based on the hypothesis on a key role of supramolecular (domain) organization of plasma cell membrane and immunoreceptor interactions with cytoskeleton. With respectto essential physiological importance of these processes we expect that the results of our basic research will become a solid basis for development of reagents and procedures suitable for practical use in diagnostics and therapy of seriousimmunopathological disorders (allergies and other hypersensitivities, autoimmune and lymphoproliferative diseases)."@en . . "0"^^ . "Center of molecular and cellular immunology"@en . "Membrane receptors; membrane microdomains; supramolecular organization; immunoreceptors; cytokines; hormones; cytoskeleton; immunopathological disorders"@en . "LN00A026" . " hormones" . " supramolecular organization" . . " membrane microdomains" . . " immunoreceptors" . . "Membrane receptors" .