"Mechanisms of Neuropathic Pain States"@en . . "1"^^ . . . "neuropathic pain" . "http://www.isvav.cz/projectDetail.do?rowId=LH12058"^^ . . "2012-03-01+01:00"^^ . " TRPV1" . . "7"^^ . "7"^^ . . " synaptic transmission" . . "2015-12-31+01:00"^^ . . " chemotherapy" . . "2015-02-16+01:00"^^ . . "Mechanizmy vzniku neuropatick\u00FDch stav\u016F" . . . "C\u00EDlem tohoto projektu je zjistit vliv modulace synaptick\u00E9ho p\u0159enosu na m\u00ED\u0161n\u00ED \u00FArovni na rozvoj stav\u016F neuropatick\u00E9 bolesti. Budou studov\u00E1ny neuropatick\u00E9 stavy na modelech po po\u0161kozen\u00ED m\u00ED\u0161n\u00EDho a perifern\u00EDho nervu a tak\u00E9 po aplikaci platinov\u00FDch chemoterapeutik. Zaveden\u00ED a studium modelu neuropatie po aplikaci chemoterapeutik ve spolupr\u00E1ci s profesorem Doughertym v USA bude tak\u00E9 jedn\u00EDm z hlavn\u00EDch c\u00EDl\u016F t\u00E9to dvoustrann\u00E9 spolupr\u00E1ce. Na modelech neuropatie bude studov\u00E1na p\u0159edev\u0161\u00EDm \u00FAloha modulace presynaptick\u00FDch TRPV1 receptor\u016F na prim\u00E1rn\u00EDch aferentn\u00EDch zakon\u010Den\u00EDch v m\u00ED\u0161e. Objasn\u011Bn\u00ED mechanizm\u016F modulace nociceptivn\u00EDho p\u0159enosu v tomto projektu, m\u016F\u017Ee p\u0159isp\u011Bt k z\u00EDsk\u00E1n\u00ED nov\u00FDch p\u0159\u00EDstup\u016F l\u00E9\u010Dby pacient\u016F s bolestmi neuropatick\u00E9ho p\u016Fvodu." . . . . "The aim of this project proposal is to study the influence of synaptic transmission modulation of nociceptive signalling at the spinal cord level in neuropathic pain states. Neuropathic conditions will be studied using models of peripheral and spinal nerve injury and also after application of platinum chemotherapeutics. The introduction and investigation of chemotherapy induced model of neuropathy will be done in cooperation with professor Dougherty (USA) and will be also one of the major goals of this cooperation. The role of presynaptic TRPV1 receptors modulation on the endings of primary afferents in the spinal cord will be the main focus of this study. Learning the mechanisms of nociceptive modulation in this project may help to determine new targets for therapy of neuropathic pain patients."@en . . "LH12058" . "0"^^ . "neuropathic pain; synaptic transmission; chemotherapy; cytokines; TRPV1; spinal cord"@en . " cytokines" . "0"^^ . . . . "2014-03-06+01:00"^^ .