. "LH12049" . . "2012-03-01+01:00"^^ . . "2015-02-16+01:00"^^ . . . " mouse model" . "1"^^ . . "The aim of the project is generation and validation of a new, generally applicable genetic tool, which will facilitate identification of genes that control susceptibility to various common diseases, including different cancers, infectious and allergic diseases, metabolic diseases, and others. Because identification of such genes, although extremely important, is time consuming, laborious and expensive, we propose to develop and test a novel genetic tool - the Fine Mosaic Chromosomes strains (FMC strains), which will make gene identification faster (about three times) and less expensive (about six times). To validate this novel genetic tool, we will test its performance on genetic analysis of model infection by parasite Leishmania major and on the model of susceptibility to lung and colon cancer."@en . . "3"^^ . "2015-12-31+01:00"^^ . . "0"^^ . "3"^^ . . "0"^^ . . . . . . . " infection" . "C\u00EDlem projektu je vytvo\u0159en\u00ED nov\u00E9ho n\u00E1stroje pro \u0159e\u0161en\u00ED jednoho z hlavn\u00EDch probl\u00E9m\u016F p\u0159i identifikaci gen\u016F, kter\u00E9 kontroluj\u00ED n\u00E1chylnost ke vzniku r\u016Fzn\u00FDch obecn\u011B roz\u0161\u00ED\u0159en\u00FDch onemocn\u011Bn\u00ED jako jsou r\u016Fzn\u00E9 typy rakoviny, infek\u010Dn\u00ED a alergick\u00E9 nemoci, poruchy metabolismu a dal\u0161\u00ED. Proto\u017Ee identifikace kontroln\u00EDch gen\u016F, ovliv\u0148uj\u00EDc\u00EDch vn\u00EDmavost k t\u011Bmto onemocn\u011Bn\u00EDm je pracn\u00E1, drah\u00E1 a pomal\u00E1, navrhujeme pou\u017Eit\u00ED nov\u00E9ho mapovac\u00EDho syst\u00E9mu \u2013 jemn\u011B mosaikov\u00FDch chromosom\u016F (FMC), kter\u00FD mapov\u00E1n\u00ED usnadn\u00ED, zlevn\u00ED (asi \u0161estkr\u00E1t) a urychl\u00ED (p\u0159ibli\u017En\u011B t\u0159ikr\u00E1t). Abychom ov\u011B\u0159ili funk\u010Dnost a efektivnost na\u0161eho nov\u00E9ho syst\u00E9mu, otestujeme ho na genetick\u00E9 anal\u00FDze modelov\u00E9 infekce parazitem Leishmania major a na modelu vn\u00EDmavosti k rakovin\u011B plic a st\u0159eva." . " resistance genes" . "Nov\u00E1 genomick\u00E1 strategie pro rychlou identifikaci gen\u016F kontroluj\u00EDc\u00EDch vznik infek\u010Dn\u00EDch nemoc\u00ED a rakoviny" . "Novel genomic strategy; Fine Mosaic Chromosomes; increased analytic efficiency; resistance genes; mouse model; infection; cancer"@en . "2014-03-06+01:00"^^ . "New Genomic Strategy for Rapid Identification of Genes Controlling Development of Infections and Cancer"@en . . "Novel genomic strategy" . . "http://www.isvav.cz/projectDetail.do?rowId=LH12049"^^ . " Fine Mosaic Chromosomes" . . " increased analytic efficiency" . .