. "http://www.isvav.cz/projectDetail.do?rowId=LH11015"^^ . . . "Study of immediate changes after epileptic seizures elicited at different stages of postnatal development"@en . "Postictal period lasts much longer than epileptic seizure itself and therefore it markedly compromise quality of life of epileptic patients. The aim of this study is to analyze mechanisms responsible for changes during postictal period. The most conspicuous phenomenon during this period is postictal refractoriness, therefore it will be used as the main indicator of postictal changes. Pharmacological experiments will demonstrate which inhibitory systems participate in this phenomenon after two different types of epileptic seiyures elicited by electrocal stimulation of cerebral cortex in rats. Postictal refractoriness is absent in immature brain therefore ontogenetic study will serve to elucidate its development and possible pharmacological manipulation. The final goal is to find treatment which will alleviate negative signs of postictal period but wich will not increase a danger of generation of the second epiletic seizure."@en . . . . "1"^^ . . "3"^^ . . "LH11015" . . "0"^^ . "3"^^ . . "0"^^ . "2011-03-01+01:00"^^ . "2014-12-31+01:00"^^ . . . . . . . "epileptic seizures postictal period postnatal development cerebral cortex electrophysiology pharmacology behavior rat"@en . . . "C\u00EDlem projektu je anal\u00FDza mechanism\u016F postikt\u00E1ln\u00ED deprese, obdob\u00ED, kter\u00E9 v\u00FDrazn\u011B zhor\u0161uje kvalitu \u017Eivota pacient\u016F s epilepsi\u00ED. Na\u0161\u00ED hypot\u00E9zou je, \u017Ee zm\u011Bny v postikt\u00E1ln\u00EDm obdob\u00ED jsou v\u00FDrazem aktivity mechanism\u016F, kter\u00E9 ukon\u010Dily z\u00E1chvat. Budeme proto hledat mo\u017Enosti, jak ovlivnit obdob\u00ED po z\u00E1chvatu ani\u017E bychom zv\u00FD\u0161ili nebezpe\u010D\u00ED vzniku nov\u00E9ho z\u00E1chvatu. V\u00FDvojov\u00E1 \u010D\u00E1st studie se zam\u011B\u0159\u00ED na dozr\u00E1v\u00E1n\u00ED mechanism\u016F zastavuj\u00EDc\u00EDch z\u00E1chvaty. Prvo\u0159ad\u00FD c\u00EDle je v t\u00E9to \u010D\u00E1sti projektu naj\u00EDt mo\u017Enosti, jak zastavit dlouhotrvaj\u00EDc\u00ED z\u00E1chvaty v nezral\u00E9m mozku - pochopiteln\u011B bez toho, abychom navodili negativn\u00ED zm\u011Bny v postikt\u00E1ln\u00ED f\u00E1zi." . "Studium bezprost\u0159edn\u00EDch zm\u011Bn po epileptick\u00E9m z\u00E1chvatu vyvolan\u00E9m v r\u016Fzn\u00FDch stadi\u00EDch postnat\u00E1ln\u00EDho v\u00FDvoje" . "2015-02-16+01:00"^^ . "2013-03-06+01:00"^^ .