" Enzyme" . "0"^^ . . "LG14009" . "0"^^ . . . "2014-04-01+02:00"^^ . "1"^^ . "0"^^ . "Struktura a funkce protein\u016F pro biotechnologie a v\u00FDvoj l\u00E9\u010Div" . "The project goal is to elucidate, in collaboration with the European infrastructure Instruct, principles of function of selected target enzymes and receptors based on structural studies, to design protein modifications for the purpose of altered properties and suggest inhibitors of function as potential lead compounds of new drugs. Achieved results will have impact in biotechnological applications and in fight against cancer, fungal diseases or against pathogens such as leishmania, legionella or trypanosoma."@en . "0"^^ . "2016-12-31+01:00"^^ . . "C\u00EDlem projektu je ve spolupr\u00E1ci s evropskou infrastrukturou Instruct objasnit principy funkce vybran\u00FDch c\u00EDlov\u00FDch enzym\u016F a receptor\u016F na z\u00E1klad\u011B strukturn\u00EDch studi\u00ED, navrhnout modifikace protein\u016F za \u00FA\u010Delem zm\u011Bny vlastnost\u00ED a navrhnout inhibitory funkce jako potenci\u00E1ln\u00ED v\u00FDchoz\u00ED l\u00E1tky nov\u00FDch l\u00E9\u010Div. Dosa\u017Een\u00E9 v\u00FDsledky budou m\u00EDt dopad v biotechnologick\u00FDch aplikac\u00EDch a v boji s rakovinou, pl\u00EDs\u0148ov\u00FDmi onemocn\u011Bn\u00EDmi anebo s patogeny jako jsou leishmania, legionela nebo trypanosoma." . . . " X-ray structure" . . "Protein; Enzyme; Receptor; X-ray structure; Structure-function relationship; Mutagenesis; Enzyme optimization; Selective inhibition; Drug lead; Cancer; Parasitic diseases; Fungal diseases; Degradation of dangerous substances"@en . . . . . . "2014-05-02+02:00"^^ . " Selective inhibition" . . . . "Structure and function of proteins for biotechnologies and drug design"@en . " Receptor" . . "http://www.isvav.cz/projectDetail.do?rowId=LG14009"^^ . " Enzyme optimization" . " Parasitic diseases" . . . "2015-02-16+01:00"^^ . " Fungal diseases" . "Protein" . " Cancer" . " Drug lead" . " Mutagenesis" . . " Structure-function relationship" .