. . . " sirtuins" . . . "0"^^ . . . "inhibitors; sirtuins; stem cells; acetylated adenosine diphosphoribose"@en . . "2014-05-19+02:00"^^ . "1"^^ . . . "0"^^ . " stem cells" . "LD14128" . . "0"^^ . . . . "C\u00EDlem pro]ektu je synt\u00E9za inhibitor\u016F sirtuin\u016F strukturn\u011B vych\u00E1zej\u00EDc\u00EDch z produktu jejich enzymatick\u00E9 reakce, acetylovan\u00E9 adenosin difosforibosy. Syntetizovan\u00E9 budou zejm\u00E9na bisfosfon\u00E1tov\u00E9 deriv\u00E1ty acetylovan\u00E9 adenosin difosforibosy, u nich\u017E bude acetylov\u00E1 funkce z\u00E1kladn\u00ED molekuly nahrazena alkylkarbon\u00E1tovou nebo alkylkarbam\u00E1tovou funkc\u00ED pro zlep\u0161en\u00ED stability t\u011Bchto deriv\u00E1t\u016F v\u016F\u010Di ester\u00E1z\u00E1m. Bisfosfon\u00E1tov\u00E1 funkce nam\u00EDsto pyrofosf\u00E1tu by m\u011Bla zajistit stabilitu fin\u00E1ln\u00EDch deriv\u00E1t\u016F v\u016F\u010Di p\u016Fsoben\u00ED NUDlX hydrol\u00E1z. V r\u00E1mci projektu bude nejprve \u0159e\u0161ena syntetick\u00E1 p\u0159\u00EDprava zvolen\u00FDch deriv\u00E1t\u016F acetylovan\u00E9 adenosin difosforibosy, je\u017E budou n\u00E1sledn\u011B testov\u00E1ny na biologickou aktivitu na jejich schopnost inhibovat SIRT1." . "Synthesis of sirtuin inhibitors"@en . . . "0"^^ . . "inhibitors" . "The aim of this project is to synthesize sirtuin inhibitors, structurally related to the product of their enzymatic reaction, acetylated adenosine diphosphoribose. These inhibitors will have the acetyl functionality of mother molecule exchanged for alkylcarbonate or alkylcarbamate functionality for the enhancement of their stability towards esterases. Bisphosphonate linkage instead of pyrophosphate should enhance the stability of final derivatives towards NUDIX hydrolases. During the project, the synthesis of designed derivatives will be carried out first, and then these derivatives will be tested for their ability to inhibit SIRT1."@en . "Synt\u00E9za inhibitor\u016F sirtuin\u016F" . "2015-04-29+02:00"^^ . "2016-03-27+01:00"^^ . "2014-04-01+02:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=LD14128"^^ . . .