. . "http://www.isvav.cz/projectDetail.do?rowId=LD14009"^^ . . "LD14009" . "Synthesis of compounds affecting mitochondrial enzymes as potential drugs for Alzheimer disease"@en . "2015-11-30+01:00"^^ . . . "1"^^ . . "0"^^ . . "Alzheimer disease, mitochondrial enzymes, modulators, synthesis, in vitro evaluation, molecular modelling"@en . "0"^^ . . "0"^^ . "2014-05-19+02:00"^^ . " in vitro evaluation" . "P\u0159\u00EDprava slou\u010Denin ovliv\u0148uj\u00EDc\u00EDch mitochondri\u00E1ln\u00ED enzymy jako potenci\u00E1ln\u00EDch l\u00E9\u010Div Alzheimerovy nemoci" . "2015-04-29+02:00"^^ . . " synthesis" . "0"^^ . . . . " modulators" . " mitochondrial enzymes" . "Alzheimer disease" . "The main aim of the project is synthesis, in vitro evaluation, molecular modelling and structure-activity relationship determination of novel modulators of mitochondrial enzymes. These compounds have potential to block interaction of beta-amyloid with mitochondrial enzymes. The novel compounds will be prepared on University of Hradec Kralove and in vitro tested on University of St. Andrews. Furthermore, the molecular modelling studying the modulator-enzyme interactions and structure-activity relationship determination will be done on University of Hradec Kralove."@en . "C\u00EDlem projektu je p\u0159\u00EDprava, in vitro testov\u00E1n\u00ED, molekul\u00E1rn\u00ED modelov\u00E1n\u00ED a hodnocen\u00ED vztah\u016F mezi strukturou a aktivitou nov\u00FDch modul\u00E1tor\u016F mitochondri\u00E1ln\u00EDch enzym\u016F. Nov\u00E9 modul\u00E1tory mitochondri\u00E1ln\u00EDch enzym\u016F se budou od st\u00E1vaj\u00EDc\u00EDch li\u0161it strukturou, kde bude p\u0159i n\u00E1vrhu jejich struktury kladen d\u016Fraz na ovlivn\u011Bn\u00ED v\u00FDznamn\u00FDch mitochondri\u00E1ln\u00EDch enzym\u016F pomoc\u00ED variabiln\u00EDch funk\u010Dn\u00EDch skupin (UHK). P\u0159ipraven\u00E9 slou\u010Deniny budou testov\u00E1ny in vitro pomoc\u00ED standardn\u00EDch a zaveden\u00FDch metodik (University of St. Andrews). V r\u00E1mci spolupr\u00E1ce COST s pracovi\u0161t\u011Bm ve Spojen\u00E9m kr\u00E1lovstv\u00ED budou vybran\u00ED kandid\u00E1ti testov\u00E1ni tak\u00E9 pomoc\u00ED dal\u0161\u00EDch (pokro\u010Dil\u00FDch) in vitro metodik (University of St. Andrews). U vybran\u00FDch slou\u010Denin budou pomoc\u00ED technik molekul\u00E1rn\u00EDho modelov\u00E1n\u00ED zji\u0161t\u011Bny mo\u017En\u00E9 interakce s mitochondri\u00E1ln\u00EDmi enzymy (UHK). Na z\u00E1klad\u011B v\u00FDsledk\u016F in vitro a v\u00FDsledk\u016F molekul\u00E1rn\u00EDho modelov\u00E1n\u00ED budou ur\u010Deny vztahy mezi strukturou a aktivitou u p\u0159ipraven\u00FDch slou\u010Denin (UHK)." . . . "2014-04-01+02:00"^^ . . . . . .