"spinocerebellar ataxia type 2; neurotransplantation; genetic background"@en . "My\u0161i SCA2 linie Q58-11 byly detailn\u011B fenotypov\u011B charakterizov\u00E1ny. Byl posouzen vliv genetick\u00E9ho pozad\u00ED na fenotyp pokusn\u00FDch my\u0161\u00ED. Byla testov\u00E1na experiment\u00E1ln\u00ED neurotransplanta\u010Dn\u00ED terapie my\u0161\u00ED SCA2. \u010C\u00E1st v\u00FDsledk\u016F byla zpracov\u00E1na formou 1 \u010Dl\u00E1nku v\u00A0\u010Dasopise s\u00A0impakt faktorem, 1 \u010Dl\u00E1nku v\u00A0recenzovan\u00E9m \u010Dasopise a prezentov\u00E1na formou 4 sjezdov\u00FDch abstrakt."@cs . "LD12056" . . "Phenotype of the SCA2 mice (Q58-11 line) was characterized. The effect of the genetic background on the phenotype of the experimental mice was assessed. Experimental neurotransplantation therapy of the SCA2 mice was tested. A part of the results was described 1 article in a journal with an impact factor and in 1 article in a peer reviewed journal and presented in 4 conference abstracts."@en . "http://www.isvav.cz/projectDetail.do?rowId=LD12056"^^ . "2013-11-30+01:00"^^ . . . . "Neurotransplanta\u010Dn\u00ED terapie u my\u0161\u00EDho modelu spinocerebel\u00E1rn\u00ED ataxie typu 2" . . "spinocerebellar ataxia type 2" . "2012-03-01+01:00"^^ . . . . . "C\u00EDlem projektu je: 1. Detailn\u00ED charakterizace zm\u011Bn nervov\u00FDch funkc\u00ED u my\u0161\u00ED SCA2 a zkoum\u00E1n\u00ED vlivu genetick\u00E9ho pozad\u00ED na projevy mutace SCA2 k posouzen\u00ED, zda existuj\u00ED geny, kter\u00E9 mohou tyto projevy modifikovat. 2. Studovat u my\u0161\u00ED SCA2 vliv intracerebel\u00E1rn\u00ED transplantace embryon\u00E1ln\u00ED tk\u00E1n\u011B moze\u010Dku na nervov\u00E9 funkce naru\u0161en\u00E9 degenerativn\u00EDm onemocn\u011Bn\u00EDm a hodnotit hladinu vybran\u00FDch trofick\u00FDch faktor\u016F a sign\u00E1ln\u00EDch molekul pro posouzen\u00ED hypot\u00E9zy, \u017Ee p\u016Fsoben\u00ED embryon\u00E1ln\u00EDho transplant\u00E1tu m\u016F\u017Ee b\u00FDt zprost\u0159edkov\u00E1no produkc\u00ED t\u011Bchto l\u00E1tek." . "0"^^ . . " neurotransplantation" . "4"^^ . "0"^^ . "The aims of the project are: 1. Detailed characterisation of behavioural abnormalities in SCA2 mice and investigation of the effect of genetic background on the manifestation of the SCA2 mutation to assess whether there are genes which could modify the manifestation of the mutation. 2. To study the effect of intracerebellar transplantation of embryonic cerebellar tissue on neural functions deteriorated by the degenerative disease in SCA2 mice and to evaluate the level of selected trophic factors and signal molecules to assess the hypothesis that the effect of embryonic grafts could be mediated by production of such substances."@en . "4"^^ . . "1"^^ . "2013-02-25+01:00"^^ . "Neurotransplantation therapy in the mouse model of spinocerebellar ataxia type 2"@en . . . . "2014-06-30+02:00"^^ . . . . . . .