. "Identifikace nov\u00FDch funkc\u00ED gen\u016F a jejich produkt\u016F vytipovan\u00FDch na z\u00E1klad\u011B anal\u00FDzy genom\u016F modelov\u00FDch organism\u016F s terapeutick\u00FDm a biotechnologick\u00FDm potenci\u00E1lem." . "Functional genetics; transfection; reverse genetics; protists; invertebrates; insects"@en . "The research plan has been solved in accordance with the task. A number of original results has been achieved, namely theoretical as well as the results with possibilities for a direct application. The results are original findings, which were published in international scientific journals. FUGEN Center established methods for cell transformations and reverse genetics for new model organisms."@en . . "Center for Functional Genetics"@en . "2011-12-31+01:00"^^ . . " protists" . "http://www.isvav.cz/projectDetail.do?rowId=LC07032"^^ . "The project is focused on functional studies of genes and their products with therapeutic and biotechnological potential using novel model organisms. The organisms include those with negative impact on quality of human life such as direct human and animal pathogens and vectors of infectious agents. In the first phase, advanced methods of molecular genetics will be established and/or optimalized in these organisms. In the second phase, the genes of interest will be selected on the basis of genomic, proteomic, and transcriptomic analyses with particular interest in genes associated with development of human diseases. The gene selection will be focused on factors of pathogenicity, oncoproteins, components of FeS assembly machinery including frataxin, nuclear receptors, circadian clock genes, developmental genes, etc. The function of selected genes will then be tested using the newly established systems as well as with the aid of the classical yeast model."@en . "1"^^ . "2012-07-03+02:00"^^ . "3"^^ . . "0"^^ . . "2007-04-01+02:00"^^ . "Centrum funk\u010Dn\u00ED genetiky" . "Projekt byl \u0159e\u0161en v souladu se zad\u00E1n\u00EDm. Byla dosa\u017Eena \u0159ada origin\u00E1ln\u00EDch v\u00FDsledk\u016F a to jak teoretick\u00FDch tak i v\u00FDsledk\u016F s mo\u017Enost\u00ED p\u0159\u00EDm\u00E9 aplikace. V\u00FDsledkem jsou zcela p\u016Fvodn\u00ED poznatky, kter\u00E9 byly publikov\u00E1ny v mezin\u00E1rodn\u00EDch v\u011Bdeck\u00FDch \u010Dasopisech. Centrum FUGEN zavedlo postupy pro transformaci bun\u011Bk a postupy reverzn\u00ED genetiky pro nov\u00E9 modelov\u00E9 organismy."@cs . . "Functional genetics" . . . . . " reverse genetics" . . " invertebrates" . . . . "LC07032" . . . "2011-02-10+01:00"^^ . . "92"^^ . . . "92"^^ . " transfection" .