. . . " gene expression" . "2007-04-01+02:00"^^ . "Within the Center, we made significant progress particularly in the characterization of molecular mechanisms of action/drug resistance of anticancer drugs, biomarkers, the study of Pseudallescheria sp. proteome and introduction of new proteomic methods based on mass spectrometry. We have also organized international conferences(DDPEO, CEEPC), workshops and symposia of national significancance."@en . . . . . " cancer biology" . "1"^^ . . . . " therapeutic targets" . "Oncoproteomics Centre"@en . . . . "V r\u00E1mci Centra se n\u00E1m poda\u0159ilo dos\u00E1hnout v\u00FDznamn\u00E9ho pokroku zejm\u00E9na v oblasti charakterizace molekul\u00E1rn\u00EDch \u00FA\u010Dink\u016F a mechanism\u016F rezistence nov\u00FDch protin\u00E1dorov\u00FDch l\u00E9\u010Div, biomarker\u016F, v oblasti toxikologie hub \u0159\u00E1du Pseudallescheria a ve v\u00FDvoji nov\u00FDch metod hmotnostn\u00ED spetkrometrie. S pomoc\u00ED Centra byly organizov\u00E1ny mezin\u00E1rodn\u00ED konference DDPEO a CEEPC a tak\u00E9 semin\u00E1\u0159e a konference m\u00EDstn\u00EDho v\u00FDznamu."@cs . . "http://www.isvav.cz/projectDetail.do?rowId=LC07017"^^ . " prognostic and predictive marker" . . " cytoprotection" . "2012-07-03+02:00"^^ . " cytotoxicity" . "proteome; proteomics; posttranslational modifications; biomedicine; cancer biology; gene expression; diagnostics; prognostic and predictive marker; therapeutic targets; multi-drug resistance; cytoprotection; cytotoxicity; cell cycle; cell metabolism"@en . . " posttranslational modifications" . " multi-drug resistance" . " diagnostics" . "86"^^ . "C\u00EDlem projektu je s pomoc\u00ED proteomick\u00E9ho profilov\u00E1n\u00ED identifikovat nov\u00E9 c\u00EDle pro l\u00E9\u010Diva, diagnostick\u00E9, prognostick\u00E9 a prediktivn\u00ED markery n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED, zlep\u0161it mo\u017Enosti v\u00FDchovy student\u016F a pos\u00EDlit n\u00E1rodn\u00ED transla\u010Dn\u00ED proteomick\u00FD v\u00FDzkum." . " cell cycle" . "86"^^ . "Centrum n\u00E1dorov\u00E9 proteomiky" . "proteome" . " biomedicine" . "LC07017" . "2011-12-31+01:00"^^ . . "2011-02-10+01:00"^^ . . . . "3"^^ . " proteomics" . "0"^^ . "The aim of proposed research program concerns the proteomic profiling of cancer cell with a perspective towards a new diagnostic and treatment modalities, particularly individualized/personalized therapy and targeted therapy of tumors and their complications. The main topics of interest involve the modulation of gene expression, induction of multidrug resistance, proteomic signatures of anticancer drugs in treated cancer cells, diagnostic, prognostic and predictive significance of selected genes in tumors or patient populations and developments of novel methods for identification of tumor-drug interactions. Oncoproteomics Centre - research consortium of recognized national research and clinical centers will also contribute to the strengthening of translational research with direct impacts on quality of life, creation of intellectual property, employment of young and gifted scientists and finally to increased quality of regional research in both national and international context."@en .