"LC06035" . "\u0158e\u0161en\u00ED projektu prob\u00EDhalo v souladu se schv\u00E1len\u00FDm n\u00E1vrhem a jeho etapov\u00E9 a d\u00EDl\u010D\u00ED c\u00EDle byly spln\u011Bny. Byly z\u00EDsk\u00E1ny nov\u00E9 v\u00FDsledky v oblasti elektrochemie nukleov\u00FDch kyselin a protein\u016F. Byly zavedeny nov\u00E9 typy elektrod pro bioelektrochemickou anal\u00FDzu. Byly vyvinuty nov\u00E9 metody zna\u010Den\u00ED biopolymer\u016F. Byly z\u00EDsk\u00E1ny nov\u00E9 poznatky v oblasti struktury, interakc\u00ED a funkce protein\u016F v\u00FDznamn\u00FDch v onkologii."@cs . . "http://www.isvav.cz/projectDetail.do?rowId=LC06035"^^ . " po\u0161kozen\u00ED DNA" . " hybridizace DNA" . . . " mutantn\u00ED proteiny" . "Po dokon\u010Den\u00ED projektu lidsk\u00E9ho genomu je t\u0159eba vypracovat jednoduch\u00E9 a levn\u00E9 metody, umo\u017E\u0148uj\u00EDc\u00ED anal\u00FDzu detail\u016F genomu jednotlivc\u016F. Sv\u011Btov\u00E1 v\u011Bda se v sou\u010Dasnosti orientuje na elektrochemickou detekci DNA p\u0159i t\u00E9to anal\u00FDze. Elektroaktivita DNA byla objevena na Biofyzik\u00E1ln\u00EDm \u00FAstavu v Brn\u011B a toto pracovi\u0161t\u011B m\u00E1 v\u00EDce jak 40-letou tradici a pat\u0159\u00ED v dan\u00E9 oblasti ke sv\u011Btov\u00E9 \u0161pi\u010Dce. V posledn\u00EDch letech dos\u00E1hly partnersk\u00E9 laborato\u0159e v\u00FDznamn\u00E9ho pokroku ve v\u00FDzkumu elektrochemick\u00FDch senzor\u016F DNA i p\u0159i anal\u00FDze protein\u016Fa dal\u0161\u00EDch l\u00E1tek. Projekt vych\u00E1z\u00ED z dosa\u017Een\u00FDch v\u00FDsledk\u016F a je orientov\u00E1n na pokro\u010Dil\u00FD v\u00FDzkum vlastnost\u00ED biomakromolekul a jejich interakc\u00ED s povrchy, zvl\u00E1\u0161t\u011B s elektrodami, a na v\u00FDzkum mezimolekul\u00E1rn\u00EDch interakc\u00ED DNA a b\u00EDlkovin v\u00FDznamn\u00FDch v z\u00E1va\u017En\u00FDch chorob\u00E1ch (rakovina, Parkinsonova a Alzheimerova choroba). Na z\u00E1klad\u011B elektrochemie, miniaturizace a nanotechnologi\u00ED budou navr\u017Eeny nov\u00E9 p\u0159\u00EDstupy a metody pro modern\u00ED biologii a biomedic\u00EDnu 21. stolet\u00ED." . "Centrum biofyzik\u00E1ln\u00ED chemie, bioelektrochemie a bioanal\u00FDzy. Nov\u00E9 n\u00E1stroje pro genomiku, proteomiku a biomedic\u00EDnu." . "nukleov\u00E9 kyseliny" . "nukleov\u00E9 kyseliny, proteiny, karcinogeny, l\u00E9\u010Diva, po\u0161kozen\u00ED DNA, hybridizace DNA, interakce DNA-protein, n\u00E1dorov\u00E9 supresory, amyloidn\u00ED proteiny, mutantn\u00ED proteiny, denaturace, agregace, elektrochemie, separace, kapil\u00E1rn\u00ED elektrofor\u00E9za, hmotov\u00E1 spektromet"@en . . . . . . . "After completion of the human genome project, there is demand for simple and inexpensive methods enabling analysis of details of individuals' genomes. The contemporary world science is oriented towards utilization of electrochemical DNA detection in thisanalysis. DNA electroactivity was discovered at the Institute of Biophysics in Brno. Laboratories of this Institute belong to the world elite in this field for more than four decades. In the partner laboratories, a considerable progress has been attainedin the research of electrochemical DNA sensors as well as in analysis of proteins and other substances in recent years. This project is based on the existing results and it is oriented towards advanced studies of the properties of biomacromolecules andt heir interactions with surfaces, especially electrodes, and towards research of intermolecular interactions of DNA and/or proteins important in severe disorders (cancer, Parkinson's or Alzheimer's disease). On the basis of electrochemistry, miniaturiza"@en . " elektrochemie" . . . . "The project solution proceeded in accord with the proposal and its aims was reached. New results were obtained in the area of electrochemistry of nucleic acids and proteins. Novel electrodes for bioelectrochemical analysis were introduced. New techniques of biopolymer labeling were developed. New knowledge was attained on the structure, interactions and function of cancer-related proteins."@en . " interakce DNA-protein" . . " proteiny" . "2006-03-01+01:00"^^ . . " amyloidn\u00ED proteiny" . . " l\u00E9\u010Diva" . . "2011-12-31+01:00"^^ . . . "2011-02-11+01:00"^^ . "1"^^ . "701"^^ . "2012-07-03+02:00"^^ . " kapil\u00E1rn\u00ED elektrofor\u00E9za" . "701"^^ . "1"^^ . "4"^^ . " separace" . . "Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine."@en . " denaturace" . . " n\u00E1dorov\u00E9 supresory" . " agregace" . " karcinogeny" .