. "4"^^ . "1"^^ . . . . " substr\u00E1tov\u00E1 specifita" . "The aim of the project is to develop and optimize novel biocatalysts (dehalogenases, esterases, nitrilases, amidases, glycosidases etc.), to study their molecular structure and biocatalysis mechanisms and to introduce methods for their structure-function analysis and goal-directed improvement. Principle methods: screening of new microbial enzymes, enzyme library construction, directed evolution, cloning and expression of genes, protein crystal formation and analysis, molecular modeling, software development and modification, practical applications of enzymes to biotransformations and chemoenzymatic synthesis. The key aspect consists in the education of undergraduate and postgraduate students, the organization of methodical seminars, workshops and scientific symposia and the expansion of international contacts, particularly through participation in international projects."@en . . . " proteinov\u00E9 in\u017Een\u00FDrstv\u00ED" . "http://www.isvav.cz/projectDetail.do?rowId=LC06010"^^ . . "Center of Biocatalysis and Biotransformation created within 6-y activity over 150 original papers describing new principles of enzymatic catalysis and 4 patents were obtained. Ca 70 students defended their theses within the center activity (Bc 20, Mgr 18, PhD 41). Center organized regular courses and scientific meetings. Center members integrated into European scientific networks of excellence."@en . "V r\u00E1mci 6-ti let\u00E9 aktivity Centra biokatal\u00FDzy a biotransformac\u00ED bylo vytvo\u0159eno p\u0159es 150 p\u016Fvodn\u00EDch publikac\u00ED popisuj\u00EDc\u00EDch nov\u00E9 principy biokatal\u00FDzy a 4 patenty, d\u00E1le v Centru pracovalo ca 70 student\u016F (Bc 20, Mgr 18, PhD 41), kte\u0159\u00ED obh\u00E1jili sv\u00E9 gradua\u010Dn\u00ED pr\u00E1ce. Centrum po\u0159\u00E1dalo ka\u017Edoro\u010Dn\u011B odborn\u00E9 kursy a v\u011Bdeck\u00E1 setk\u00E1n\u00ED. \u010Clenov\u00E9 centra se zapojili do evropsk\u00FDch s\u00EDt\u00ED elitn\u00EDch v\u011Bdeck\u00FDch pracovi\u0161\u0165."@cs . " katalytick\u00E1 aktivita" . " exprese gen\u016F" . . . . . . "Centrum biokatal\u00FDzy a biotransformac\u00ED" . . . "2012-07-03+02:00"^^ . . . . "C\u00EDlem projektu je v\u00FDvoj a optimalizace nov\u00FDch biokatalyz\u00E1tor\u016F (dehalogenas, esteras, nitrilas, amidas, glykosidas a dal\u0161\u00EDch vybran\u00FDch enzym\u016F), studium mechanism\u016F biokatal\u00FDzy a molekul\u00E1rn\u00ED struktury t\u011Bchto enzym\u016F, v\u00FDvoj a zav\u00E1d\u011Bn\u00ED metod pro studium struktury a funkce enzym\u016F a pro jejich c\u00EDlenou optimalizaci. Hlavn\u00ED vyu\u017Eit\u00E9 metodiky: screening nov\u00FDch mikrobi\u00E1ln\u00EDch enzym\u016F a vytv\u00E1\u0159en\u00ED knihoven, metody \u0159\u00EDzen\u00E9 evoluce, klonov\u00E1n\u00ED a exprese gen\u016F, krystalizace protein\u016F a n\u00E1sledn\u00E1 anal\u00FDza, molekul\u00E1rn\u00ED modelov\u00E1n\u00ED, modifikace a v\u00FDvoj nov\u00E9ho software, chemoenzymov\u00E1 synt\u00E9za a biotransformace ov\u011B\u0159uj\u00EDc\u00ED praktick\u00E9 aplikace enzym\u016F. Kl\u00ED\u010Dov\u00E1 bude v\u00FDchova pregradu\u00E1ln\u00EDch a postgradu\u00E1ln\u00EDch student\u016F, organizace metodick\u00FDch semin\u00E1\u0159\u016F, workshop\u016F a v\u011Bdeck\u00FDch kongres\u016F a rozv\u00EDjen\u00ED zahrani\u010Dn\u00EDch styk\u016F p\u0159edev\u0161\u00EDm \u00FA\u010Dast\u00ED v mezin\u00E1rodn\u00EDch projektech. V posledn\u00EDm prodlou\u017Een\u00E9m roce \u0159e\u0161en\u00ED (2011)budou dokon\u010Deny experiment\u00E1ln\u00ED pr\u00E1ce, zpracov\u00E1na data, finalizov\u00E1ny publikace a doktorsk\u00E9 pr\u00E1ce." . . . "LC06010" . "193"^^ . . "2011-02-11+01:00"^^ . "enzymov\u00E1 katal\u00FDza; katalytick\u00E1 aktivita; proteinov\u00E9 in\u017Een\u00FDrstv\u00ED; substr\u00E1tov\u00E1 specifita; exprese gen\u016F; \u0159\u00EDzen\u00E1 evoluce"@en . "193"^^ . "Center of Biocatalysis and Biotransformation"@en . "2011-12-31+01:00"^^ . "2006-03-01+01:00"^^ . "0"^^ . "enzymov\u00E1 katal\u00FDza" .