"Structure, expression and interaction of the genome"@en . . "2005-06-17+02:00"^^ . "genome sequencing" . . . . "6"^^ . "translation" . . . . . "KSK5052113" . . "genetics" . "gene expression" . "0"^^ . . "developmental biology" . "chromosome aberrations" . "growth factor" . "human chromosomes 21 and 22" . "1"^^ . "http://www.isvav.cz/projectDetail.do?rowId=KSK5052113"^^ . . "transcription" . . . "104"^^ . . "104"^^ . "global genome mapping" . . "genome sequencing;molecular genetics of development;global genome mapping;human chromosomes 21 and 22;plant genome;chromosome aberrations;genetics;developmental biology;gene expression;growth factor;transcription;translation;DNA reparation"@en . . "Byly z\u00EDsk\u00E1ny poznatky o struktu\u0159e a funkci nov\u00FDch gen\u016F u \u010Dlov\u011Bka nebo u \u017Eivo\u010Di\u0161n\u00FDch a rostlinn\u00FDch modelov\u00FDch organism\u016F, o topografii interf\u00E1zn\u00EDho j\u00E1dra zdrav\u00E9 i nemocn\u00E9 bu\u0148ky, byla ov\u011B\u0159ena exprese heterologn\u00EDch pretein\u016F v rostlin\u00E1ch."@cs . "The project is oriented toward analysis of basic questions concernig gene structure and mechanisms playing a role in gene expression in selected model organisms. The results obtained will contribute significantly to our understanding of the origin of hereditary diseases and cancer, the mechanisms playing a role in resistance and susceptibility to infectious diseases of plants and animals, and they will be employed for modification of genes with the aim to obtain products useful in medicine or production of genetically modified organisms employable in medicine as a source of tissues or organs. These basic aspects of the project are elaborated in detail in programmes of individual participating Institutes of the Academy of Sciences, CR."@en . "Knowledge on the structure and function of new genes in man or in animal and plant model organisms, as well as on the topography of interphase nucleus of healthy and diseased cell was obtained; expression of heterologous proteins in plants was assessed."@en . "P\u0159edkl\u00E1dan\u00FD projekt je zam\u011B\u0159en na \u0159e\u0161en\u00ED z\u00E1kladn\u00EDch ot\u00E1zek strukturn\u00EDho uspo\u0159\u00E1d\u00E1n\u00ED gen\u016F a genom\u016F, v\u010Detn\u011B studia mechanism\u016F pod\u00EDlej\u00EDc\u00EDch se na regulaci genov\u00E9 exprese u vybran\u00FDch modelov\u00FDch organism\u016F. Z\u00EDskan\u00E9 poznatky v\u00FDznamn\u011B p\u0159isp\u011Bj\u00ED k porozum\u011Bn\u00ED vzniku d\u011Bdi\u010Dn\u00FDch a n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED, mechanism\u016Fm podmi\u0148uj\u00EDc\u00EDm rezistenci a vn\u00EDmavost k infek\u010Dn\u00EDm onemocn\u011Bn\u00EDm rostlina i \u017Eivo\u010Dich\u016F, budou vyu\u017Eity k modifikaci gen\u016F s c\u00EDlem z\u00EDskat nov\u00E9 medic\u00EDnsky vyu\u017Eiteln\u00E9 l\u00E1tky nebo geneticky modifikovan\u00E9 organismy, kter\u00E9 mohou slou\u017Eit jako zdroj medic\u00EDnsky vyu\u017Eiteln\u00FDch tk\u00E1n\u00ED a org\u00E1n\u016F. Tyto z\u00E1kladn\u00ED aspekty projektu jsou detailn\u011B rozpracov\u00E1ny v programech jednotliv\u00FDch participuj\u00EDc\u00EDch \u00FAstav\u016F AV \u010CR." . "molecular genetics of development" . . . . . "plant genome" . "Struktura, exprese a interakce genomu" .