. " rennin-angiotensin system" . "7"^^ . . "7"^^ . "Oxid dusnat\u00FD (NO) hraje d\u016Fle\u017Eitou \u00FAlohu v regulaci kardiovaskul\u00E1rn\u00EDch a ren\u00E1ln\u00EDch funkc\u00ED a jeho sn\u00ED\u017Een\u00ED m\u016F\u017Ee b\u00FDt rozhoduj\u00EDc\u00EDm faktorem p\u0159i poru\u0161e fyziologick\u00FDch mechanism\u016F co\u017E m\u016F\u017Ee p\u0159isp\u00EDvat k rozvoji ren\u00E1ln\u00EDch a kardiovaskul\u00E1rn\u00EDch poruch v\u010Detn\u011B hypertenze. Renin-angiotenzinov\u00FD syst\u00E9m (RAS) hraje rovn\u011B\u017E kl\u00ED\u010Dovou fyziologickou \u00FAlohu v regulaci ren\u00E1ln\u00EDch funkc\u00ED a krevn\u00EDho tlaku. Nicm\u00E9n\u011B zv\u00FD\u0161en\u00ED aktivity RAS p\u0159isp\u00EDv\u00E1 k patofyziologii hypertenze a vede k rozvoji oxidativn\u00EDho stresu v t\u011Ble. Tak doch\u00E1z\u00ED k d\u016Fle\u017Eit\u00E9 interakci voln\u00FDch kysl\u00EDkov\u00FDch radik\u00E1l\u016F (ROS) s NO, \u010D\u00EDm\u017E ROS sni\u017Euj\u00ED biologickou dostupnost NO, a tak p\u0159isp\u00EDvaj\u00ED k prohlouben\u00ED patofyziologick\u00FDch \u00FA\u010Dink\u016F RAS vedouc\u00EDch k rozvoji hypertenze. C\u00EDlem na\u0161\u00ED studie je zjistit \u00FAlohu interakce NO, oxidativn\u00EDho stresu a RAS v regulaci ren\u00E1ln\u00EDch funkc\u00ED a v rozvoji renovascul\u00E1rn\u00ED hypertenze na modelu my\u0161\u00ED s deficientn\u00ED endoteli\u00E1ln\u00ED synt\u00E1zu NO a tak\u00E9 vliv antioxida\u010Dn\u00ED terapie u tohoto modelu hypertenze." . "Nitric oxide (NO) plays and important role in the regulation of cardiovascular and renal function. Its deficiency can cause impairments of physiological mechanisms possibly leading to renal and cardiovascular dysfunction including hypertension. Renin-angiotensin system (RAS) also plays a key role in the regulation of renal function and blood pressure. However, an enhanced activity of RAS can contribute in pathophysiology of hypertension and induces oxidative stress in the body. Reactive oxygen species (ROS), particularly superoxide can quickly interact with NO diminishing its biological availability. Thus this interaction contributes in pathophysiological effects of RAS in the development of hypertension. The aim of our proposal is to assess the role of interaction of NO, oxidative stress and RAS in the regulation of renal function and blood pressure in deficient mice for endothelial NO synthase with induced renovascular hypertension and effects of antioxidant therapy in these mice."@en . "The role of interaction between nitric oxide, oxidative stress and renin-angiotensin system in the regulation of renal function and blood pressure in mice lacking gene for endothelial nitric oxide synthase with renovascular hypertension"@en . . . . " oxidative stress" . . "2011-06-14+02:00"^^ . . "\u00DAloha interakce mezi oxidem dusnat\u00FDm, oxidativn\u00EDm stresem a renin-angiotenzinov\u00FDm syst\u00E9mem v regulaci ren\u00E1ln\u00EDch funkc\u00ED a krevn\u00EDho tlaku u my\u0161\u00ED s deficientn\u00ED endotheli\u00E1ln\u00ED synt\u00E1zou oxidu dusnat\u00E9ho s renovaskul\u00E1rn\u00ED hypertenz\u00ED" . . . . "2008-01-01+01:00"^^ . . "nitric oxide; oxidative stress; rennin-angiotensin system; renovascular hypertension."@en . "Z \u00FA\u010Delov\u00E9 podpory GAAV bylo dosa\u017Eeno nov\u00FDch poznatk\u016F v experiment\u00E1ln\u00ED medic\u00EDn\u011B, kter\u00E9 byly publikov\u00E1ny v osmi origin\u00E1ln\u00EDch prac\u00EDch v odborn\u00FDch \u010Dasopisech a m\u011Bli by p\u0159isp\u011Bt ke zlep\u0161en\u00ED pohledu na \u00FA\u010Dinnost antihypertenzn\u00ED terapie v klinick\u00E9 medic\u00EDn\u011B."@cs . "0"^^ . . . "1"^^ . . "2010-12-31+01:00"^^ . . "2010-03-09+01:00"^^ . "0"^^ . . . . "The financial support from GAAV led to the several new insights in experimental medicine that have been published in eight scientific journals and they should provide a better understanding of antihypertensive treatment efficiency in clinical medicine."@en . "http://www.isvav.cz/projectDetail.do?rowId=KJB502030801"^^ . "nitric oxide" . "KJB502030801" .