. "nanofibers" . . . "2012-02-29+01:00"^^ . " biodegradable polymers" . " pharmacokinetics" . "Biokompatibiln\u00ED nanovl\u00E1kenn\u00E9 konstrukty vytv\u00E1\u0159ej\u00EDc\u00ED nov\u00E9 l\u00E9kov\u00E9 formy pro aplikaci biologicky a farmakologicky aktivn\u00EDch l\u00E1tek" . " transplantation" . "Byly p\u0159ipraveny a charakterizov\u00E1ny nov\u00E9 formy konstrukt\u016F nanovl\u00E1kenn\u00FDch nosi\u010D\u016F s kmenov\u00FDmi bu\u0148kami nebo nesouc\u00EDch farmakologicky aktivn\u00ED l\u00E1tku a na modelech povrchov\u00FDch tk\u00E1\u0148ov\u00FDch defekt\u016F byl prok\u00E1z\u00E1n jejich v\u00FDznamn\u00FD terapeutick\u00FD potenci\u00E1l."@cs . "http://www.isvav.cz/projectDetail.do?rowId=KAN200520804"^^ . "26"^^ . " immunomodulation" . . " immunosuppressives" . "26"^^ . . "Navrhovan\u00FD projekt se zab\u00FDv\u00E1 v\u00FDzkumem v oblasti vyu\u017Eit\u00ED polymern\u00EDch nanovl\u00E1kenn\u00FDch nosi\u010D\u016F k vytv\u00E1\u0159en\u00ED nov\u00FDch l\u00E9kov\u00FDch forem slou\u017E\u00EDc\u00EDch k c\u00EDlen\u00FDm a \u0159\u00EDzen\u00FDm aplikac\u00EDm farmakologicky a biologicky aktivn\u00EDch l\u00E1tek, zejm\u00E9na pak v oblasti imunofarmakologie. Zkoum\u00E1ny budou jak techniky adsorpce a absorpce biologicky aktivn\u00EDch l\u00E1tek na nanovl\u00E1kenn\u00E9 nosi\u010De, tak i mo\u017Enost vyu\u017Eit\u00ED nanovl\u00E1kenn\u00FDch dvojvrstev k enkapsulaci bun\u011B\u010Dn\u00FDch kultur uvol\u0148uj\u00EDc\u00EDch imunologicky aktivn\u00ED l\u00E1tky. Biokompatibilita a funk\u010Dnost t\u011Bchto konstrukt\u016F budou ov\u011B\u0159ov\u00E1ny in vitro v tk\u00E1\u0148ov\u00FDch kultur\u00E1ch a testov\u00E1ny v experiment\u00E1ln\u00EDch zv\u00ED\u0159ec\u00EDch modelech. Kone\u010Dn\u00FDm c\u00EDlem je navr\u017Een\u00ED a v\u00FDroba zcela nov\u00FDch l\u00E9kov\u00FDch forem zalo\u017Een\u00FDch na nanovl\u00E1kenn\u00FDch technologi\u00EDch a \u0161iroce vyu\u017Eiteln\u00FDch k l\u00E9\u010Debn\u00FDm \u00FA\u010Del\u016Fm v r\u016Fzn\u00FDch oblastech medic\u00EDny." . . " tissue engineering" . . . . . "nanofibers; nanofiber scaffolds; tissue engineering; biodegradable polymers; hydrogels; pharmacokinetics; immunosuppressives; cytokines; stem cells; immunomodulation; transplantation; therapy of surface lesions"@en . " hydrogels" . . . . . "Novel constructs of nanofiber scaffolds containing stem cells or pharmacologically active drugs were prepared and characterized. The therapeutic potential of these constructs was proved in experimental models of surface injuries and defects."@en . . "2012-12-31+01:00"^^ . "KAN200520804" . "2008-01-01+01:00"^^ . "Biocompatible nanofiber scaffolds forming novel drug matrices for the application of biologically and pharmacologically active substances"@en . . . "1"^^ . . "2013-03-26+01:00"^^ . . " nanofiber scaffolds" . "4"^^ . " cytokines" . "0"^^ . . "The aim of the proposed project is research in the field of polymeric nanofibers and their use for the construction of novel drug carriers suitable for the application of biologically and pharmacologically active substances. Both the absorption and adsorption of biologically active substances to nanofiber scaffolds and the utilization of nanofiber bilayers to encapsulate drug-producing cells will be explored. The biocompatibility and biological properties of these new drug carriers will be tested and characterized in vitro in tissue culture and in experimental animal models. The ultimate goal of this research is the design and production of novel drug carriers based on nanofiber technology that can be widely used for the treatment of serious illnesses."@en . " stem cells" .