" microbiology" . "New nanoparticles for ultrastructural diagnostics"@en . "72"^^ . . "72"^^ . . . "5"^^ . "http://www.isvav.cz/projectDetail.do?rowId=KAN200520704"^^ . . . " diagnostics" . "Projekt m\u00E1 poprv\u00E9 v historii ultrastruktur\u00E1ln\u00ED cytochemie umo\u017Enit sou\u010Dasn\u00E9 citliv\u00E9 zna\u010Den\u00ED alespo\u0148 \u010Dty\u0159 antigen\u016F. Obsahuje t\u0159i hlavn\u00ED c\u00EDle: 1) Vyvinout sadu nano\u010D\u00E1stic o velikostech 5-15 nm s r\u016Fzn\u00FDm tvarem nebo prvkov\u00FDm slo\u017Een\u00EDm, vhodnou pro ultrastruktur\u00E1ln\u00ED cytochemii. V\u00FDsledkem bude sada alespo\u0148 \u010Dty\u0159 odli\u0161iteln\u00FDch stabiln\u00EDch nano\u010D\u00E1stic pro sou\u010Dasnou detekci v elektronov\u00FDch mikroskopech. 2) P\u0159ipravit stabiln\u00ED detek\u010Dn\u00ED sadu nano\u010D\u00E1stic konjugovan\u00FDch s protil\u00E1tkami pro v\u00EDcen\u00E1sobn\u00E1 ultrastruktur\u00E1ln\u00ED zna\u010Den\u00ED v biomedic\u00EDn\u011B a podrobn\u011B charakterizovat jejich vlastnosti pro TEM a SEM. V\u00FDsledn\u00E1 detek\u010Dn\u00ED sada bude p\u0159ed\u00E1na pro komer\u010Dn\u00ED realizaci a roz\u0161\u00ED\u0159en\u00ED mezi v\u011Bdeckou komunitu. 3) Vyvinout diagnostick\u00FD n\u00E1stroj a standardizovanou proceduru pro ultrastruktur\u00E1ln\u00ED charakterizaci spektra antigen\u016F virov\u00FDch vakc\u00EDn/frakc\u00ED u vakc\u00EDny proti p\u0159iu\u0161nic\u00EDm. V\u00FDsledek umo\u017En\u00ED zkvalitnit vakc\u00EDnu a kontrolu p\u0159\u00EDtomnosti pot\u0159ebn\u00FDch imuniza\u010Dn\u00EDch antigen\u016F a bude komer\u010Dn\u011B vyu\u017E\u00EDv\u00E1n." . . " ultrastructure" . . "2011-12-31+01:00"^^ . " metal nanoparticles" . "electron microscopy; ultrastructure; metal nanoparticles; colloidal gold; quantum dots; diagnostics; immunocytochemistry; cytology; histology; microbiology; virology; pathology"@en . " immunocytochemistry" . "C\u00EDle projektu byly spln\u011Bny. V\u00FDstupy tvo\u0159\u00ED: 23 odborn\u00FDch \u010Dl\u00E1nk\u016F, 2 \u010Desk\u00E9 patenty a 4 u\u017Eitn\u00E9 vzory, 43 funk\u010Dn\u00ED vzorky, 1 certifikovan\u00E1 metodika, 43 v\u011Bdeck\u00FDch sd\u011Blen\u00ED na konferenc\u00EDch, zorganizov\u00E1ny byly 4 v\u011Bdeck\u00E9 konference a 15 mikroskopick\u00FDch semin\u00E1\u0159\u016F."@cs . . . . " colloidal gold" . " cytology" . . "The aims were fulfilled with following outcomes: 23 research articles, 2 Czech patents and 4 utility models, 43 functional samples, 1 certified protocol, 43 conference communications, 4 scientific conferences and 15 microscopy courses were organized."@en . " histology" . . . . . "Nov\u00E9 nanopartikule pro ultrastruktur\u00E1ln\u00ED diagnostiku" . "KAN200520704" . . . "electron microscopy" . . "0"^^ . . . "2007-01-01+01:00"^^ . "2012-03-21+01:00"^^ . "The project aims to allow for the first time a sensitive simultaneous detection of at least four antigens. It has three main aims: 1) Development of a set of nanoparticles sized 5-15 nm with various shapes or elemental composition, suitable for ultrastructural cytochemistry. The result will be a set of at least four distinguishable electron-stable nanoparticles for simultaneous detection. 2) Preparation of a stable detection set of nanoparticles conjugated with antibodies for multiple ultrastructural labelings in biomedicine, and a description of their properties for TEM and SEM. The detection set will be commercially used and distributed to the scientific community. 3) Development of a diagnostic tool and a standardized procedure for ultrastructural characterization of antigen spectra in viral vaccines/fractions in mumps vaccine. The result will allow for a vaccine improvement and a control of presence of required immunization antigens; it will be commercially used."@en . "1"^^ . "2011-03-18+01:00"^^ . " virology" . " quantum dots" .