" nanoparticles" . "1"^^ . . . . "4"^^ . "0"^^ . . " immunoextraction" . "2008-01-01+01:00"^^ . . . . "http://www.isvav.cz/projectDetail.do?rowId=KAN200380801"^^ . "Poda\u0159ilo se p\u0159ipravit generick\u00E9 hormon\u00E1ln\u00ED protil\u00E1tky a z nich imunonanosorbenty. Kombinace s UPLC/MS/MS umo\u017Enila monitorov\u00E1n\u00ED fytohormon\u016F na atomol\u00E1rn\u00ED \u00FArovni. \u0158ada technologi\u00ED byla patentov\u011B chr\u00E1n\u011Bna a n\u00E1sledn\u011B licencov\u00E1na do v\u00FDrobn\u00ED praxe."@cs . "107"^^ . "nanotechnologies" . "nanotechnologies; nanoparticles; immunoextraction; hormones; mass spectrometry"@en . "107"^^ . "Hlavn\u00EDm c\u00EDlem projektu je vyvinout nov\u00E9 diagnostick\u00E9 %22imunonanotechnologie%22 umo\u017E\u0148uj\u00EDc\u00ED vysoce citlivou detekci (atomol\u00E1rn\u00ED i men\u0161\u00ED) a kvantifikaci hormon\u00E1ln\u00EDch l\u00E1tek rostlinn\u00E9ho a \u017Eivo\u010Di\u0161n\u00E9ho p\u016Fvodu na \u00FArovni bun\u011B\u010Dn\u00E9, tk\u00E1\u0148ov\u00E9 a pletivov\u00E9. Projekt bude zahrnovat p\u0159\u00EDpravu 4 z\u00E1kladn\u00EDch komponent t\u011Bchto nanotechnologi\u00ED: 1)nov\u00E9 typy antigen\u016F indukuj\u00EDc\u00EDch tvorbu generick\u00FDch poly- \u010Di monoklon\u00E1ln\u00EDch protil\u00E1tek; 2)v\u00FDvoj nov\u00E9 generace imunosorbent\u016F na b\u00E1zi funkcionalizovan\u00FDch magnetick\u00FDch nano\u010D\u00E1stic a v\u00FDvoj a optimalizace mikro- a nanoimunoextrakce; 3)v\u00FDvoj nov\u00E9 generace analytick\u00FDch p\u0159\u00EDstup\u016F pro stanoven\u00ED l\u00E1tek hormon\u00E1ln\u00ED povahy pomoc\u00ED kombinovan\u00E9 immunoafintn\u00ED chromatografie a UPLC/MS/MS na atomol\u00E1rn\u00ED \u00FArovni; 4)aplikace imunonanotechnologi\u00ED na vzorky pletiv, tk\u00E1n\u00ED a bun\u011Bk, v\u010Detn\u011B aplikace mikrodisekce. V\u00FDsledkem projektu by m\u011Blo b\u00FDt v\u00EDce jak 20 nov\u00FDch licencovan\u00FDch produkt\u016F, kter\u00E9 budou nab\u00EDdnuty spolupracuj\u00EDc\u00EDm firm\u00E1m. P\u0159edpokl\u00E1d\u00E1me, \u017Ee v\u011Bt\u0161ina produkt\u016F bude exportov\u00E1na." . "Imunonanotechnologie pro diagnostiku l\u00E1tek hormon\u00E1ln\u00ED povahy" . . "2013-03-26+01:00"^^ . . . "2012-12-31+01:00"^^ . . . . " hormones" . "Immunonanotechnologies for hormone diagnostic"@en . . . "2012-02-29+01:00"^^ . . . . . . "Aim of the project is to develop %22immunonanotechnologies%22 for sensitive detection (atomoles and lower) of hormonal substances of plant and animal origin at cell and tissue levels. The project will be focused on development of the following 4 main components: 1)new type of antigens inducing production of generic antibodies (group specific)polyclonal and monoclonal antibodies; 2)development of new generations of immunosorbents on the bases of functionalised magnetic nanoparticles together with preparation and optimization of micro- and nanoimunoextraction; 3)development of new generation of labelled internal probes for hormone quantification using UPLC/MS/MS at atomolar levels; 4)application of immunonanotechnologies to tissue and cell samples, testing of microdissection. The main result of the project will be more than 20 new products licensed to private firms in the Czech Republic. We propose that many of these products will be exported soon after the start of production."@en . "KAN200380801" . "Generic phytohormone antibodies and derived immunonanosorbents have been prepared. Combination with UPLC/MS/MS made it possible to analyze different phytohormones at attomolar levels. The technologies were patented and licensed to a commercial partner."@en .