. . . . . "0"^^ . . . " nanofibres" . "1"^^ . . . "KAN200100801" . . "2008-01-01+01:00"^^ . . . "2012-02-29+01:00"^^ . . "biocompatible nanocarbon materials" . "Bioaktivn\u00ED biokompatibiln\u00ED povrchy a nov\u00E9 nanostrukturovan\u00E9 kompozity pro aplikace v medic\u00EDn\u011B a farmacii" . "10"^^ . . . " smart surface functionalisation" . . "\u00DA\u010Delem navrhovan\u00E9ho mezioborov\u00E9ho projektu je p\u0159iprava a studium nanostrukturovan\u00FDch materi\u00E1l\u016F s bioaktivn\u00EDmi povrchy, jako nap\u0159. nov\u00FDch nosi\u010D\u016F l\u00E9\u010Div, nanovl\u00E1ken a materi\u00E1l\u016F na b\u00E1zi nanouhl\u00EDku, tj. uhl\u00EDkov\u00FDch nanotub, nanodiamantu a polymer\u016F, s v\u00FDzna\u010Dnou biokompatibilitou, pro c\u00EDlov\u00E9 vyu\u017Eit\u00ED v medic\u00EDn\u011B, farmacii a diagnostice. Povlakov\u00E1n\u00ED keramick\u00FDch nano\u010D\u00E1stic a nanovl\u00E1ken polymery \u010Di diamantem nukleac\u00ED metodami samouspo\u0159\u00E1d\u00E1n\u00ED a vyu\u017Eit\u00ED unik\u00E1tn\u011B n\u00EDzk\u00E9 teploty r\u016Fstu diamantu pod 150\u00B0C umo\u017En\u00ED p\u0159\u00EDpravu nov\u00FDch nanokompozit\u016F s povrchy vhodn\u00FDmi pro funkcionalizaci biomolekulami. Nosi\u010De l\u00E9\u010Div budou studov\u00E1ny pro imobilizaci makrocyklick\u00FDch slou\u010Denin, p\u0159edev\u0161\u00EDm porfyrin\u016F a metaloporfyrin\u016F resp. protein\u016F tak i polysacharid\u016F. Aktivn\u00ED povrchy budou studov\u00E1ny pro transport DNA, peptid\u016F a cytostatik s c\u00EDlen\u00FDm terapeutick\u00FDm \u00FA\u010Dinkem a sou\u010Dasnou ochranou p\u0159ed biodegradac\u00ED. Chemick\u00E9 modifikace povrch\u016F budou zam\u011B\u0159eny na aplikace v d\u00E1vkov\u00E1n\u00ED l\u00E9\u010Div a pro bioaktivn\u00ED biokompatibiln\u00ED chirurgick\u00E9 stenty." . "Bioactive Biocompatible Surfaces and Novel Nanostructured Composites for Applications to Medicine and Drug Delivery"@en . "2013-03-26+01:00"^^ . . "179"^^ . "179"^^ . . "The proposed interdisciplinary project deals with preparation of novel biocompatible nanostructured materials with bioactive surfaces for applications in medicine. Nano-precursory drug delivery systems with increased bioactivity and stability will be developed as well as materials such as nanocrystalline diamond, polymers and carbon nanotubes, nanofibres and other drug vehicles. Key factors that influence bio/non-bio interfacial properties as the charge, polarity, mobility and geometric organization of molecular motifs at surfaces will be studied, providing the surface cues conditioning cellular and colloidal interactions with on the molecular expression level. Integrated smart systems with surfaces functionalized by synthesised biomolecules as porphyrins, biopolymers, and polysaccharides will be studied for transport of DNA, peptides and cytostatics with targeted therapeutic action and biodegradation protection and for drug-diluted stents."@en . "http://www.isvav.cz/projectDetail.do?rowId=KAN200100801"^^ . . "BIOKOM vedl k d\u016Fle\u017Eit\u00FDm v\u00FDstup\u016Fm v oblasti nanotechnologi\u00ED a konvergentn\u00EDch v\u011Bd. 207 publikac\u00ED, 2 v\u011Bdeck\u00E9 knihy, 14 kapitol ve v\u011Bdeck\u00FDch kn\u00EDh\u00E1ch a 28 patent\u00FA polo\u017Eilo z\u00E1klady intezivn\u00EDch spoluprac\u00ED a zavedlo aplikace sp2 a sp3 uhl\u00EDku a nanomateri\u00E1l\u016F v \u010CR."@cs . "2012-12-31+01:00"^^ . . "biocompatible nanocarbon materials; nanofibres; smart surface functionalisation; drug delivery"@en . "BIOKOM led to important outputs in Nanotechnology and Converging Sciences. 207 publications, 2 books, 14 book chapters and 28 patents laid down a basis for introduction of sp3 and sp2 carbon nanomatarials in the society and new intensive collaborations."@en .