. . . . "http://www.isvav.cz/projectDetail.do?rowId=IBS4055109"^^ . . "1"^^ . "Byla objevena nov\u00E1 skupina v\u00FDznamn\u00FDch antivirotik; jde o acyklick\u00E9 nukleosidfosfon\u00E1ty s otev\u0159en\u00FDm kruhem. Jsou to deriv\u00E1ty 2,4-diaminopyrimidinu substituovan\u00E9 6-fosfono-alkoxyskupinou."@cs . "antineoplastic;antileukemic;antitumor;cytostatic;nucleotide analogs;drug design;medicinal chemistr;antimetabolites;mechanisms;transplantable"@en . . "C\u00EDlem projektu je v\u00FDvoj potenci\u00E1ln\u00EDch l\u00E9\u010Div pro zv\u00FD\u0161en\u00ED \u00FA\u010Dinnosti chemotherapie neoplasi\u00ED (n\u00E1dor\u016F, leukemi\u00ED). Projekt vych\u00E1z\u00ED z existuj\u00EDc\u00EDch rozs\u00E1hl\u00FDch poznatk\u016F a zku\u0161enosti v\u00FDzkumn\u00E9ho t\u00FDmu, t\u00FDkaj\u00EDc\u00EDch se nov\u00E9ho typu l\u00E1tek, objeven\u00FDch na UOCHB a vych\u00E1z\u00ED z p\u0159edpokladu jejich synergick\u00FDch \u00FA\u010Dink\u016F s jin\u00FDmi l\u00E9ky p\u016Fsob\u00EDc\u00EDmi na odli\u0161n\u00FDch mechanistick\u00FDch z\u00E1kladech a na sn\u00ED\u017Een\u00E9 pravd\u011Bpodobnosti vzniku mnoho\u010Detn\u00E9 l\u00E9kov\u00E9 resistence. Zahrnuje preklinick\u00FD v\u00FDzkum skupiny origin\u00E1ln\u00EDch l\u00E1tek vybran\u00FDch na z\u00E1klad\u011B strukturn\u011B aktivitn\u00EDho studia, tzv. druh\u00E9 generace fosfon\u00E1t\u016F acyklick\u00FDch nukleosid\u016F, p\u0159edev\u0161\u00EDm l\u00E1tek ze skupiny N6-substituovan\u00FDch deriv\u00E1t\u016F 2,6-diaminopurinu s r\u016Fzn\u00FDm postrann\u00EDm \u0159et\u011Bzcem, u jejich\u017E z\u00E1stupc\u016F ji\u017E byla nalezena v\u00FDzna\u010Dn\u00E1 cytostatick\u00E1 aktivita. L\u00E1tky maj\u00ED i jin\u00E9 v\u00FDznamn\u00E9 \u00FA\u010Dinky, p\u0159edev\u0161\u00EDm protivirov\u00FD a imunostimula\u010Dn\u00ED. Obsahem projektu jsou n\u00E1vrhy struktury a synt\u00E9za nov\u00FDch l\u00E1tek, jejich biochemick\u00E9 studium (mechanismus \u00FA\u010Dinku) a prov\u011B\u0159en\u00ED biologick\u00FDch \u00FA\u010Dink\u016F in vitro i in vivo." . . "0"^^ . . . . "0"^^ . "The aim of this project is to develop novel drug candidates for improvement of the chemotherapy of tumors and malignancies of the haematopoietic system. The project results from an already existing knowledge and experience. The original compounds which are subject of this examination are based on a new structural principle which warrants their suitable clinical parameters, in particular their synergistic action with other anticancer drugs acting on different principles and, a comparative durability against multilple drug resistence (MDR). It concerns preclinical investigation of the 2nd generation of the so-called acyclic nucleoside phosphonates, namely N6-substituted derivatives of 2,6-diaminopurine with prospective antineoplastic activity, and their congeners. Additional activities of these compouds encompass intiviral and immunomodulatory activity. The project involves design, synthesis, biochemical (mode of action) and biological evaluation of selected drug candidates."@en . . "Acyclic nucleoside phosponates with antineoplastic activity"@en . . . . "Acyklick\u00E9 nukleosidfosfon\u00E1ty s antineoplastick\u00FDm \u00FA\u010Dinkem" . "IBS4055109" . "antileukemic" . . . "antitumor" . "antimetabolites" . "medicinal chemistr" . . . "drug design" . "cytostatic" . . "nucleotide analogs" . "mechanisms" . "25"^^ . . "25"^^ . . "A series of promising antivirals was discovered; these open ring acyclic nucleoside phosphonates are derivatives of 2,4-diaminopyrimidine substituted with 6-phosphonoalkoxy group."@en . "2006-06-19+02:00"^^ . "antineoplastic" .