"http://www.isvav.cz/projectDetail.do?rowId=IAAX01110901"^^ . " adrenergic signaling" . . . . . "Adaptace na chronickou kontinu\u00E1ln\u00ED hypoxii sni\u017Euje velikost infarktu myokardu u normotenzn\u00EDch i hypertenzn\u00EDch potkan\u016F. V\u00FDznamnou \u00FAlohu v mechanismu protekce srdce hraje aktivace antioxida\u010Dn\u00EDch ochrany, z\u00E1n\u011Btliv\u00E9 reakce a zm\u011Bny energetick\u00E9ho metabolismu."@cs . "\u00DAloha adrenergn\u00ED signalizace a oxidativn\u00EDho stresu v molekul\u00E1rn\u00EDch mechanismech kardioprotektivn\u00EDho p\u016Fsoben\u00ED chronick\u00E9 hypoxie" . "Hlavn\u00EDm c\u00EDlem tohoto projektu je zlep\u0161it na\u0161e porozum\u011Bn\u00ED molekul\u00E1rn\u00EDm mechanism\u016Fm kardioprotektivn\u00EDho p\u016Fsoben\u00ED chronick\u00E9 hypoxie. Budeme detailn\u011B analyzovat \u00FAlohu adrenergn\u00ED signalizace a reaktivn\u00EDch kysl\u00EDkat\u00FDch radik\u00E1l\u016F (ROS) v normoxick\u00E9m a chronicky hypoxick\u00E9m myokardu. Citlivost k akutn\u00EDmu ischemicko-reperfuzn\u00EDmu po\u0161kozen\u00ED bude studov\u00E1na paraleln\u011B se zm\u011Bnami na molekul\u00E1rn\u00ED \u00FArovni. Zvl\u00E1\u0161tn\u00ED pozornost bude v\u011Bnov\u00E1na mitochondri\u00E1ln\u00EDm zdroj\u016Fm ROS. Z\u00EDskan\u00E9 poznatky budou ov\u011B\u0159eny za patofyziologick\u00FDch podm\u00EDnek ischemie u m\u00E1lo odoln\u00FDch spont\u00E1nn\u011B hypertenzn\u00EDch potkan\u016F (SHR) a u nov\u00E9ho konplastick\u00E9ho kmene vytvo\u0159en\u00E9ho z SHR vnesen\u00EDm mitochondri\u00E1ln\u00EDho genomu z vysoce odoln\u00E9ho kmene potkan\u016F Brown Norway. Objasn\u011Bn\u00ED vztah\u016F mezi adrenergn\u00ED signalizac\u00ED a ROS v endogenn\u00EDm protektivn\u00EDm mechanismu chronick\u00E9 hypoxie m\u016F\u017Ee napomoci k identifikaci molekul\u00E1rn\u00EDch terapeutick\u00FDch c\u00EDl\u016F vhodn\u00FDch pro navozen\u00ED dlouhodob\u00E9ho zv\u00FD\u0161en\u00ED odolnosti myokardu k ischemii." . "The major aim of this project is to advance our understanding of molecular mechanisms underlying cardioprotective effects of chronic hypoxia. We will analyze in detail the role of adrenergic and reactive oxygen species (ROS) signaling. Susceptibility to acute ischemia/reperfusion injury will be studied in parallel with changes at the molecular level. A special attention will be devoted to the mitochondrial sources of ROS. Received knowledge will be further corroborated under pathophysiological situations of ischemia in low-resistant spontaneously hypertensive rats (SHR) and in a novel conplastic strain created from SHR by introducing the mitochondrial genome from a highly ischemia-resistant rat strain Brown Norway. Delineation of the relationship between adrenergic and ROS signaling in the endogenous protective mechanism of chronic hypoxia may help to identify molecular therapeutic targets suitable for induction of long-lasting increase in myocardial tolerance to ischemia."@en . "heart; cardioprotection; chronic hypoxia; adrenergic signaling; oxidative stress"@en . " cardioprotection" . . . . . "The role of adrenergic signaling and oxidative stress in molecular mechanisms of cardioprotection induced by chronic hypoxia"@en . "Adaptation to chronic continuous hypoxia reduces myocardial infarct size in both normotensive and hypertensive rats. Antioxidative defence, inflammation and modifications of energetic metabolism play a role in the mechanism of myocardial protection."@en . " chronic hypoxia" . "2014-04-14+02:00"^^ . . . "8"^^ . "heart" . "8"^^ . . "2013-02-27+01:00"^^ . . . "0"^^ . "3"^^ . "IAAX01110901" . "1"^^ . . . "2009-01-01+01:00"^^ . "2013-12-31+01:00"^^ . . . . . .