. "0"^^ . " electrical activity" . "Electronically and chemically optimized nanocrystalline diamond structures for bio-applications"@en . "carbon nanoparticles" . " tissue engineering" . "2009-01-01+01:00"^^ . . " biomolecules" . . . "1"^^ . " self-organization" . . " biosensors" . "2012-02-29+01:00"^^ . "This interdisciplinary project focuses on a basic research and standardization of electronic grade nanocrystalline diamond (NCD) films for biotechnology, mainly for tissue engineering. Its technological part is oriented on the CVD growth of B-doped NCD films, whereas their electronic, morphological and chemical properties will be studied and optimized with respect to the cell cultivation requirements. The selective growth of nano-sized NCD structures, by the self-assembly process from polymer composites, will be one of the most challenging parts. After proper functionalization, the NCD structures will be used for the realization of electronic devices able to recognize specific biochemical and biological reactions during the cell cultivation. B-doped NCD films will be used for electrically-induced and controlled differentiation of mesenchymal stem cells into osteoblasts. The realized cell lab-on-chip will represent a system with future application in the area of regenerative medicine."@en . . "42"^^ . "IAAX00100902" . "42"^^ . "http://www.isvav.cz/projectDetail.do?rowId=IAAX00100902"^^ . . " cell growth" . " nanotechnology" . "Planned results were achieved. In this interdisciplinary project, nanodiamond layers were grown, characterized and used as substrates for cell growth. 28 papers were published in impacted journals, 1 patent was granted."@en . . " cell adhesion" . "2012-12-31+01:00"^^ . " biochips" . "Elektronicky a chemicky optimalizovan\u00E9 struktury nanokrystalick\u00E9ho diamantu pro bioaplikace" . . "Tento mezioborov\u00FD projekt je zam\u011B\u0159en na systematick\u00FD z\u00E1kladn\u00ED v\u00FDzkum a standardizaci vyu\u017Eit\u00ED vrstev nanokrystalick\u00E9ho diamantu (NKD) elektronick\u00E9 kvality pro biotechnologie, zejm\u00E9na pro tk\u00E1\u0148ov\u00E9 in\u017Een\u00FDrstv\u00ED. Technologick\u00E1 \u010D\u00E1st projektu je orientov\u00E1na na p\u0159\u00EDpravu vrstev b\u00F3rem dopovan\u00FDch NKD metodou CVD, p\u0159i\u010Dem\u017E budou studov\u00E1ny a optimalizov\u00E1ny elektronick\u00E9, morfologick\u00E9 a chemick\u00E9 vlastnosti vrstev pro pot\u0159eby kultivace bun\u011Bk. V\u00FDznamnou \u010D\u00E1st\u00ED projektu bude selektivn\u00ED r\u016Fst nanostruktur NKD procesem spont\u00E1nn\u00ED organizace z polymern\u00EDch kompozit\u016F. Struktury NKD funkcionalizovan\u00E9 vhodn\u00FDmi ligandy budou pou\u017Eity ke konstrukci elektronick\u00FDch prvk\u016F, schopn\u00FDch rozpoznat specifick\u00E9 biochemick\u00E9 a biologick\u00E9 d\u011Bje p\u0159i kultivaci bun\u011Bk. B\u00F3rem dopovan\u00E9 vrstvy NKD budou vyu\u017Eity pro navozen\u00ED a \u0159\u00EDzen\u00ED diferenciace mesenchym\u00E1ln\u00EDch kmenov\u00FDch bun\u011Bk v osteoblasty vlivem elektrick\u00E9ho pole. Bio\u010Dipy vytvo\u0159en\u00E9 v tomto projektu budou prezentovat syst\u00E9my s budouc\u00EDm potenci\u00E1ln\u00EDm uplatn\u011Bn\u00EDm v regenerativn\u00ED medic\u00EDn\u011B." . "carbon nanoparticles; boron-doped nanocrystalline diamond; nanotechnology; biosensors; biochips; self-organization; electrical activity; biomolecules, tissue engineering; stem cells; bone implants; cell adhesion; cell growth; cell differentiation"@en . "Pl\u00E1novan\u00FDch v\u00FDsledk\u016F bylo dosa\u017Eeno. Interdisciplin\u00E1rn\u00ED projekt spojil technologii p\u0159\u00EDpravy nano-diamantov\u00FDch vrstev a jejich charakterizaci s r\u016Fstem bun\u011B\u010Dn\u00FDch struktur na t\u011Bchto substr\u00E1tech. Bylo publikov\u00E1no 28 impaktovan\u00FDch publikac\u00ED a 1 patent."@cs . . . . "2014-02-12+01:00"^^ . . . . " stem cells" . " boron-doped nanocrystalline diamond" . " bone implants" . . . . "2"^^ . . .