. . "Ion implantation" . " UV-irradiation" . . . . " differentiation" . " protein adsorption" . "IAA7011908" . " carbonization" . "Modifikovat fyzik\u00E1ln\u011B-chemick\u00E9 vlastnosti povrchu snytet. polymer\u016F, p\u0159edev\u0161\u00EDm polystyrenu a polyetylenu tak, aby bylo dosa\u017Eeno co nejvy\u0161\u0161\u00EDho po\u010Dtu a stupn\u011B rozprost\u0159en\u00ED c\u00E9vn\u00EDch endotelov\u00FDch a hladk\u00FDch svalov\u00FDch bun\u011Bk v podm\u00EDnk\u00E1ch in vitro. Polymery budou oz\u00E1\u0159eny proudem iont\u016F o relativn\u011B vysok\u00E9 energii a d\u00E1vce (>- 150 keV a >-5x10 na 14 iont\u016F/cm2), jako\u017E i hmotnosti (ionty halogen\u016F a vz\u00E1cn\u00FDch plyn\u016F), co\u017E povede k v\u00FDrazn\u00E9 karbonizaci povrchu polymeru. Dal\u0161\u00EDm zp\u016Fsobem modifikace bude chem. dotace polymer\u016F uhl\u00EDkem a nav\u00E1z\u00E1n\u00ED funk\u010Dn\u00EDch skupin podporuj\u00EDc\u00EDch adhesi bun\u011Bk (aminoskupin a ev. i dal\u0161\u00EDch) do m\u00EDst s voln\u00FDmi radik\u00E1ly a dvojn\u00FDmi vazbami vznikaj\u00EDc\u00EDmi p\u0159i iontov\u00E9m oz\u00E1\u0159en\u00ED. Na takto modifikovan\u00FDch polymerech o\u010Dek\u00E1v\u00E1me zv\u00FD\u0161enou adsorpci glykoprotein\u016F (vitronektin a fibronektin z kultiva\u010Dn\u00EDho m\u00E9dia, zprost\u0159edkuj\u00EDc\u00EDch vlastn\u00ED bun\u011B\u010Dnou adhesi." . . . "Improved cell adhesion on physico-chemically modified polymer surfaces"@en . . "http://www.isvav.cz/projectDetail.do?rowId=IAA7011908"^^ . . . "Ion implantation; UV-irradiation; polymers; oxidation; carbonization; wettability; protein adsorption; amino acid grafting; vascular smooth muscle cells; endothelial cells; keratinocytes; adhesion; proliferation; differentiation; tissue engineering;"@en . " amino acid grafting" . . "The aim of the Project is to develop modifications of the physico-chemical surface properties of synthetic polymers, namely polystyrene, polyethylene, which would be anhancing adherence of the vascular endothelial and smooth muscle cells in culture. The polymers will be irradiated by ions of halogens or rare gases applied at >- 150 keV and >-5x10 14 ions/cm2 which will cause carbonization of a thin layer of the polymer. As an alternative method, chemical doping of polymers with carbon black will be used. The free radicals and double bonds formed in the irradiated polymers will be utilized also for grafting additional functional groups supporting cell adhesion (amine and other functional groups). We expect increased adsorption of adhesion-mediating glycoproteins (vitronectin, fibronectin) from the culture medium to the modified polymers and higher expression of integrin receptors for these glycoproteins by the seeded cells."@en . . " proliferation" . " keratinocytes" . " vascular smooth muscle cells" . "Oz\u00E1\u0159en\u00ED polystyrenu a polyethylenu ionty F+, Ar+, O+ a C+ (energie 23-150 keV, d\u00E1vka 3x1013-1015 iont\u016F/cm2) v\u00FDrazn\u011B zv\u00FD\u0161ilo adhesi a diferenciaci c\u00E9vn\u00EDch hladk\u00FDch svalov\u00FDch a endotelov\u00FDch bun\u011Bk in vitro bez v\u00FDznamn\u00E9 stimulace jejich proliferace."@cs . " tissue engineering" . "18"^^ . "2007-01-15+01:00"^^ . "18"^^ . " oxidation" . " endothelial cells" . " polymers" . "Zv\u00FD\u0161en\u00ED adhesn\u00ED schopnosti bun\u011Bk povrchov\u00FDmi modifikacemi polymern\u00EDch nosi\u010D\u016F" . " adhesion" . . "0"^^ . . "0"^^ . " wettability" . . "3"^^ . . .