"IAA601680801" . " immunomodulation" . "http://www.isvav.cz/projectDetail.do?rowId=IAA601680801"^^ . . "2012-12-31+01:00"^^ . "2012-02-29+01:00"^^ . " tissue cultures" . . . . . "13"^^ . " trimeric GTP-binding proteins" . . "2008-01-01+01:00"^^ . "Modulace subpopulac\u00ED imunocyt\u016F transmiterov\u00FDmi syst\u00E9my ve v\u00FDvoji obrann\u00FDch mechanism\u016F" . "13"^^ . . "Jak v neuroendokrinn\u00EDm tak imunitn\u00EDm syst\u00E9mu je zaji\u0161t\u011Bn spole\u010Dn\u00FD reperto\u00E1r receptor\u016F a ligand\u016F peptidov\u00FDch a nepeptidov\u00FDch, neurotransmiter\u016F, cytokin\u016F a chemokin\u016F pro intrasyst\u00E9movou, ale i intersyst\u00E9movou dvousm\u011Brnou komunikaci. Medi\u00E1tory obou syst\u00E9m\u016F (cytokiny, katecholaminy, O2 radik\u00E1ly a NO) mohou ovlivnit odpov\u011B\u010F p\u0159\u00EDslu\u0161n\u00FDch G protein sp\u0159a\u017Een\u00FDch (GPC) receptor\u016F modulac\u00ED efektorov\u00FDch struktur GPC kinas. C\u00EDlem projektu je nal\u00E9zt p\u0159\u00ED\u010Dinn\u00E9 souvislosti mezi receptory (noradrenergn\u00EDmi, dopaminov\u00FDmi a adenosinov\u00FDmi) a v\u00FDvojem jednotliv\u00FDch subpopulac\u00ED imunokompetentn\u00EDch bun\u011Bk v ontogenezi spont\u00E1nn\u00ED i antigenn\u011B modulovan\u00E9. Bude vyu\u017Eit prase\u010D\u00ED model, stejn\u011B jako techniky in vitro a bun\u011B\u010Dn\u00E9 linie, analyzovan\u00E9 metodami imunocytochemick\u00FDmi, cytofluorometrick\u00FDmi a biochemick\u00FDmi. Projekt p\u0159isp\u011Bje krom\u011B bli\u017E\u0161\u00EDho pozn\u00E1n\u00ED v\u00FDvojov\u00E9 imunologie tak\u00E9 k pochopen\u00ED souvislost\u00ED interakce hostitel-patogen, ur\u010Duj\u00EDc\u00EDho to krit\u00E9ria v patogenetick\u00E9m procesu a n\u00E1sledn\u00E9 obrann\u00E9 strategii." . "Modulation of immunocyte subpopulations by transmitter systems during development of defense mechanisms"@en . "1"^^ . "2014-02-12+01:00"^^ . . . . "CD surface markers" . . "0"^^ . "CD surface markers; developmental immunology; phagocytosis; tissue cultures; neurotransmitters; immunomodulation; cell signal transduction; trimeric GTP-binding proteins, apoptosis"@en . " cell signal transduction" . "3"^^ . . . " developmental immunology" . " phagocytosis" . . . . . " neurotransmitters" . . "Data show that natural adenosine transmitter and its adenosine receptor subtypes, G protein coupled, are regulators of events in cells of both brain and immmune system in various animal species. Total IF of publications = 21.181."@en . . "Both neuroendocrine and immune system display common repertoire of receptors and ligands of peptides or non-peptides, neurotransmitters, cytokines and chemokines in intrasystem and intersystem bidirectional communication. Mediators of both systems (cytokines, catecholamines, O2 radical and NO) can influence response of appropriated G protein coupled (GPC) receptors modulating effector structures such as GPC kinases,highly expressed on immune cells. Aim is to contribute to causal immune and physiological relationships in ontogeny, spontaneous or antigen-modulated, with pig model. Besides these studies in vitro techniques and cell lines will be used and immunocytochemical, cytofluorimetry and biochemical analyses will be performed.We suggest more detailed knowledge in developmental immunology, furthermore project can contribute to more broad consequences during host-pathogen agens interaction, critical step in pathogenetic process and subsequent defense strategy."@en . . "Data ukazuj\u00ED, \u017Ee adenosin a adenosinov\u00E9 receptory hraj\u00ED roli p\u0159i regulaci funkce bun\u011Bk jak v mozku, tak i v r\u00E1mci imunitn\u00EDho syst\u00E9mu r\u016Fzn\u00FDch \u017Eivo\u010Di\u0161n\u00FDch druh\u016F.Celkov\u00FD IF publikac\u00ED = 21,181."@cs .