. . "V\u00FDsledky uk\u00E1zaly, \u017Ee angiotensin-(1-7) je v\u00FDznamn\u00FD vazodilata\u010Dn\u00ED l\u00E1tka a \u017Ee poruch v tvorb\u011B nebo sign\u00E1ln\u00ED mechanizmu angiotenzinu-(1-7) p\u0159isp\u00EDv\u00E1 k zhor\u0161en\u00ED hypertenze u 2K1C Goldblattovy modelu hypertenze."@cs . "Data showed that angiotensin-(1-7) serves as an important vasodilatory system and that a deficiency in angiotensin-(1-7) formation or an interrupted signaling contributes to the deterioration of hypertension in 2K1C Goldblatt hypertension."@en . "http://www.isvav.cz/projectDetail.do?rowId=IAA511700701"^^ . "renin-angiotensin system" . . "IAA511700701" . " renovascular hypertension" . . . . "2010-06-08+02:00"^^ . . "2009-12-31+01:00"^^ . " Goldblatt hypertension" . "The renin-angiotensin system (RAS) plays a key role in the regulation of arterial blood pressure and in the development of hypertension. Angiotensin II has been championed for many years as the main biologically active component of the RAS that mediates through activation of AT1 receptors most physiological and pathophysiological actions of the RAS. Increasing evidence suggest that angiotensin-(1-7), a recently discovered component of the RAS, may act as an endogenous antagonist to the actions of ANG II, especially in situations when the RAS is overactivated. Therefore, the aim of the present study is to determine the role of angiotensin-(1-7) in the regulation of renal function and in the development of hypertension in two-kidney, one-clip Goldblatt hypertension, an experimental model of renovascular hypertension"@en . . "2009-04-28+02:00"^^ . . . . . . "Kl\u00ED\u010Dov\u00E1 \u00FAloha renin-angiotenzinov\u00E9ho syst\u00E9mu v regulaci ren\u00E1ln\u00EDch funkc\u00ED, objemu extracelul\u00E1rn\u00ED tekutiny a v\u00FD\u0161i arteri\u00E1ln\u00EDho krevn\u00EDho tlaku je v\u0161eobecn\u011B zn\u00E1ma. Zv\u00FD\u0161en\u00E1 aktivita RAS rovn\u011B\u017E v\u00FDznamn\u00FDm zp\u016Fsobem p\u0159isp\u00EDv\u00E1 k patofyziologii hypertenze u experiment\u00E1ln\u00EDho modelu renovaskul\u00E1rn\u00ED hypertenze, kdy se dlouhodob\u011B nalo\u017E\u00ED svorka na jednu a. renalis (tzv. %22two-kidney, one-clip, 2K1C%22 Goldbaltt\u016Fv model hypertenze). Angiotenzin II byl po dlouh\u00E1 l\u00E9ta pokl\u00E1d\u00E1n za kone\u010Dn\u00FD produkt RAS odpov\u011Bdn\u00FD za fyziologick\u00E9 a patofyziologick\u00E9 \u00FA\u010Dinky tohoto syst\u00E9mu. Ned\u00E1vn\u00E9 studie prok\u00E1zaly, \u017Ee angiotenzin-(1-7), nov\u011B objeven\u00FD komponent RAS, m\u00E1 vazodilata\u010Dn\u00ED a natriuretick\u00E9 vlastnosti a mohl by tedy b\u00FDt l\u00E1tkou, kter\u00E1 kompenzuje patofyziologick\u00E9 \u00FA\u010Dinky ANG II zejm\u00E9na za podm\u00EDnek zv\u00FD\u0161en\u00E9 aktivity RAS. C\u00EDlem studie je zjistit \u00FAlohu angiotenzinu-(1-7) v regulaci ren\u00E1ln\u00EDch funkc\u00ED a rozvoji hypertenze u 2K1C Goldblattova modelu hypertenze, co\u017E je v\u0161eobecn\u011B uzn\u00E1van\u00FD model lidsk\u00E9 renovaskul\u00E1rn\u00ED hypertenze." . . "0"^^ . "2007-01-01+01:00"^^ . . . . "renin-angiotensin system; renovascular hypertension; Goldblatt hypertension; angiotensin-(1-7)"@en . "1"^^ . . "0"^^ . "7"^^ . "7"^^ . "\u00DAloha angiotenzinu-(1-7), nov\u00E9ho komponentu renin-angiotenzinov\u00E9ho syst\u00E9mu, v patofyziologii Goldblattovsk\u00E9 hypertenze \u2013 modelu lidsk\u00E9 renovaskul\u00E1rn\u00ED hypertenze" . "The role of angiotensin-(1-7), a new component of the renin-angiotensin system, in the pathophysiology of two-kidney one-clip Goldblatt hypertension"@en .