. . . . "S vyu\u017Eit\u00EDm specifick\u00FDch protil\u00E1tek a techniky immunoblot, p\u0159\u00EDpadn\u011B dal\u0161\u00EDch metod pro stanoven\u00ED funkce GTP-vazebn\u00FDch protein\u016F (GTPganaS-, fluoridem, \u010Di forskolinem - stimulovateln\u00E1 adenylyl cyklasa, membr\u00E1nov\u00E1 rekonstituce s mutantou cyc- S49 lymfomov\u00FDch bun\u011Bk, agonistou-stimulovateln\u00E1 GTP-asa, agonistou indukovan\u00E1 v\u00FDm\u011Bny GDP-GTP), budou v hn\u011Bd\u00E9 tukov\u00E9 tk\u00E1ni identifikov\u00E1ny z\u00E1kladn\u00ED typy GTP-vazebn\u00FDch protein\u016F. V dal\u0161\u00EDm stupni budou v modelech funk\u010Dn\u00ED diferenciace a specializace dn\u011Bd\u00E9 tukov\u00E9 tk\u00E1n\u011B (ontogenetick\u00FD v\u00FDvoj, diferenciace v tk\u00E1\u0148ov\u00E9 kultu\u0159e, chladov\u00E1 adaptace, indukce obezity) charakterizov\u00E1ny jejich funk\u010Dn\u00ED i kvantitativn\u00ED zm\u011Bny. Probl\u00E9m GTP-vazebn\u00FDch protein\u016F bude sledov\u00E1n v obecn\u00E9m kontextu p\u0159enosu sign\u00E1lu p\u0159es plasmatickou membr\u00E1nu, tedy sou\u010Dasn\u011B s p\u0159\u00EDslu\u0161n\u00FDmi receptory (beta-adrenergn\u00ED) a efektory (adenylyl cyklasa)." . . "The role of GTP-binding proteins in hormonal stimulation of brown adipose tissue"@en . . . . . "http://www.isvav.cz/projectDetail.do?rowId=IAA5011501"^^ . "1"^^ . "IAA5011501" . "2"^^ . "3"^^ . . "3"^^ . "\u00DAloha GTP-vazebn\u00FDch protein\u016F v hormon\u00E1ln\u00ED stimulaci hn\u011Bd\u00E9 tukov\u00E9 tk\u00E1n\u011B" . . "0"^^ . . . .