"0"^^ . . "This project is aimed at complex studies of the molecular mechanism of anticancer activity of the new metal-based compounds and is based on recent progress reached in this field in the aplicant`s laboratory. The goal of these studies is mainly to contribute to the theoretical background for the synthesis and clinical application of platinum complexes with unique DNA binding activities capable of overcoming the problem of cellular resitance to platinum cytostatics already used in clinic and of their limited activity against the most common tumors. An important aspect of this approach is to find the DNA adduct of dinuclear platinum complexes most likely relevant to their antitumor effect, its structural features and the factors controlling its formation. Another important aspect is to examine and compare the mechanism of action of metal complexes structurally distinct from platinum anticancer drugs used in clinic."@en . "0"^^ . . . . "1"^^ . . "Vliv geometrick\u00E9 isomerisace protin\u00E1dorov\u011B \u00FA\u010Dinn\u00FDch dvojjadern\u00FDch komplex\u016F platiny na vazebn\u00E9 vlastnosti a konforma\u010Dn\u00ED zm\u011Bny DNA" . . . "IAA5004702" . "http://www.isvav.cz/projectDetail.do?rowId=IAA5004702"^^ . . "Tento projekt je zam\u011B\u0159en na komplexn\u00ED studie molekul\u00E1rn\u00EDho mechanismu protin\u00E1dorov\u00E9 \u00FA\u010Dinnosti nov\u00FDch cytostatik odvozen\u00FDch od komplex\u016F kov\u016F a je zalo\u017Een na pokroku dosa\u017Een\u00E9m v laborato\u0159i navrhovatele v t\u00E9to v\u011Bdn\u00ED oblasti. C\u00EDlem studi\u00ED popsan\u00FDch v tomto projektu je p\u0159isp\u011Bt ke zdokonalen\u00ED poznatkov\u00E9ho z\u00E1zem\u00ED pro synt\u00E9zu a klinickou aplikaci komplex\u016F platiny s unik\u00E1tn\u00EDmi vazebn\u00FDmi vlastnostmi v\u016F\u010Di DNA, kter\u00E9 jsou schopn\u00E9 p\u0159ekonat jednak probl\u00E9my bun\u011B\u010Dn\u00E9 rezistence k cytostatik\u016Fm odvozen\u00FDm od komplex\u016F kov\u016Fa jich vyu\u017E\u00EDvan\u00FDm v klinick\u00E9 praxi, jednak probl\u00E9my sovisej\u00EDc\u00ED s jejich omezenou aktivitou v nejb\u011B\u017En\u011Bj\u0161\u00EDch n\u00E1dorech. D\u016Fle\u017Eit\u00FDm aspektem tohoto p\u0159\u00EDstupu je tak\u00E9 nal\u00E9zt adukt dvojjadern\u00FDch komplex\u016F platiny na DNA, kter\u00FD je nejpravd\u011Bpodobn\u011Bj\u0161\u00EDm kandid\u00E1tem po\u0161kozen\u00ED vedouc\u00EDho k protin\u00E1dorov\u00E9mu efektu, jeho strukturn\u00ED vlastnosti a faktory, kter\u00E9 ovliv\u0148uj\u00ED jeho vznik. Dal\u0161\u00EDm d\u016Fle\u017Eit\u00FDm aspektem je zkoum\u00E1n\u00ED a srovn\u00E1n\u00ED mechanismu p\u016Fsoben\u00ED komplex\u016F platiny strukturn\u011B odli\u0161n\u00FDch od platinov\u00FDch cytostatik." . . . "Pomoc\u00ED metod mplekul\u00E1rn\u00ED biofyziky byly zji\u0161t\u011Bny modifikace DNA protin\u00E1dorov\u011B \u00FA\u010Dinn\u00FDmi polynukle\u00E1rn\u00EDmi komplexy platiny a jejich rozli\u0161en\u00ED specifick\u00FDmi proteiny. Z\u00EDskan\u00E9 v\u00FDsledky roz\u0161i\u0159uj\u00ED teoretick\u00E9 z\u00E1zem\u00ED pro p\u0159\u00EDpravu nov\u00FDch l\u00E9\u010Div proti rakovin\u011B."@cs . . . . . "15"^^ . . "15"^^ . "Effects of geometric isomerism in antitumor dinuclear platinum complexes on binding properties and conformational alterations in DNA"@en . .