. "1"^^ . . . . . " genetics" . " colorectal cancer" . "inflammation; immunity; colorectal cancer; genetics; DNA repair; germ-free animals; inflammatory bowel disease"@en . "Byla objevena a poprv\u00E9 pops\u00E1na p\u0159\u00EDtomnost \u010Dasn\u00FDch, dynamick\u00FDch a m\u011B\u0159iteln\u00FDch zm\u011Bn kolagenov\u00E9 struktury st\u0159evn\u00ED sliznice, kter\u00E9 jsou spjaty s lok\u00E1ln\u00EDmi imunologick\u00FDmi alteracemi v souvislosti s chronick\u00FDm z\u00E1n\u011Btem \u010Di z\u00E1n\u011Btem spjat\u00FDm s karcinogenez\u00ED."@cs . . "In this project we intend to evaluate genetic and immunologic findings in cancer and inflammation relationships. We will study arise of cancer in DSS-AOM induced colorectal cancers in the rat. We will look for genetic/immunologic modifications/pathways detectable both in germ-free and conventional rats as possible independent markers of cancer evolution. Data will be compared with samples from patients with inflammatory bowel diseases and cancer, looking for clinical translation (evaluation of cancer risk, early diagnosis)."@en . . "Genetics and immunity in early stages of colorectal adenocarcinoma: inflammatory environment inconventional vs germ-free animal models, and in human samples"@en . . . "http://www.isvav.cz/projectDetail.do?rowId=IAA500200917"^^ . . . "2013-12-31+01:00"^^ . . " DNA repair" . . . " germ-free animals" . . "2009-01-01+01:00"^^ . "2013-02-27+01:00"^^ . "13"^^ . "13"^^ . . "The presence of early, dynamic and measurable changes in the collagen scaffold of the mucosa, associated to local immunological alterations producing chronic inflammation or cancer-related inflammation, was discovered and was described for the first time."@en . "Genetick\u00E1 a imunologick\u00E1 studie \u010Dasn\u00FDch st\u00E1di\u00ED kolorekt\u00E1ln\u00EDho adenokarcinomu: prost\u0159ed\u00ED z\u00E1n\u011Btu na konven\u010Dn\u00EDch vs germ free zv\u00ED\u0159ec\u00EDch modelech a na vzorc\u00EDch z lidsk\u00E9 tk\u00E1n\u011B" . "inflammation" . "V tomto projektu zam\u00FD\u0161l\u00EDme charakterizovat genetick\u00E9 a imunologick\u00E9 n\u00E1lezy ve vztaz\u00EDch rakoviny a z\u00E1n\u011Btu. Studov\u00E1n bude vznik rakoviny u DSS-AOM indukovan\u00FDch n\u00E1dor\u016F tlust\u00E9ho st\u0159eva u potkana. Sledov\u00E1na bude genetick\u00E1/imunologick\u00E1 modifikace detekovateln\u00E1 u %22germ-free%22 i u konven\u010Dn\u00EDch krys jako mo\u017En\u00FD nez\u00E1visl\u00FD ukazatel v\u00FDvoje n\u00E1doru. Data budou porovn\u00E1na se vzorky pacient\u016F se st\u0159evn\u00EDm z\u00E1n\u011Btliv\u00FDm a rakovinn\u00FDm onemocn\u011Bn\u00EDm a interpretov\u00E1na do klinick\u00E9 praxe (hodnocen\u00ED rizika rakoviny, v\u010Dasn\u00E1 diagn\u00F3za)." . " immunity" . "0"^^ . . . "2014-04-14+02:00"^^ . "3"^^ . . . "IAA500200917" .